溴隱亭
| 中文名稱 | 溴隱亭 |
|---|---|
| 中文同義詞 | 2-溴-ALPHA-麥角環(huán)肽;溴隱亭(2-溴-ALPHA-麥角環(huán)肽);2-溴-12'-羥基-5'-ALPHA-異丁基-2'-異丙基麥角胺-3',6',18-三酮;溴隱亭;溴麥亭;溴麥角隱亭;溴麥角環(huán)肽;溴代麥角隱亭堿 |
| 英文名稱 | Bromocriptine |
| 英文同義詞 | (5’-alpha)-ropyl);,6’,18-trione;2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’;2-bromo-alpha-ergocryptine;2-bromo-alpha-ergokryptin;2-bromo-alpha-ergokryptine;2-bromoergocryptine;alpha-bromoergocriptine |
| CAS號(hào) | 25614-03-3 |
| 分子式 | C32H40BrN5O5 |
| 分子量 | 654.59 |
| EINECS號(hào) | 247-128-5 |
| 相關(guān)類別 | 雜質(zhì)對(duì)照品;有機(jī)中間體;Organics |
| Mol文件 | 25614-03-3.mol |
| 結(jié)構(gòu)式 |  |
溴隱亭 性質(zhì)
| 熔點(diǎn) | 215-218° (dec) |
|---|---|
| 比旋光度 | D20 -195° (c = 1 in methylene chloride) |
| 沸點(diǎn) | 891.3±65.0 °C(Predicted) |
| 密度 | 1.2734 (rough estimate) |
| 折射率 | 1.6400 (estimate) |
| 酸度系數(shù)(pKa) | pKa 4.90±0.05(80% MCS t = RT) (Uncertain) |
| 水溶解性 | 2.07mg/L(temperature not stated) |
| CAS 數(shù)據(jù)庫 | 25614-03-3(CAS DataBase Reference) |
溴隱亭為特異性下丘腦和垂體的多巴胺受體激動(dòng)劑，能直接作用于腺垂體，而抑制催乳素的分泌。適合在使用諾龍衍生物的循環(huán)中配合使用。
化學(xué)性質(zhì)
白色結(jié)晶性粉末。熔點(diǎn)215-218℃（分解）。用途
該品具有多巴胺受體的興奮作用?？赏高^血腦屏障，進(jìn)入中樞神經(jīng)內(nèi)，激動(dòng)多巴胺受體和抑制催乳素及生長(zhǎng)激素分泌作用。臨床用于帕金森氏癥、肢端肥大癥和乳溢癥等。生產(chǎn)方法
由麥角隱亭和N-溴丁二酸亞胺反應(yīng)得到。類別
有毒物質(zhì)急性毒性
高毒刺激數(shù)據(jù)
靜脈-大鼠 LD50: 72 毫克/公斤; 未報(bào)導(dǎo)-小鼠 LD50: 200 毫克/公斤可燃性危險(xiǎn)特性
熱分解排出有毒氮氧化物和溴化物煙霧儲(chǔ)運(yùn)特性
庫房通風(fēng)干燥低溫滅火劑
水,二氧化碳,沙土,泡沫,干粉安全信息
| 毒性 | An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v. |
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