SD-208
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SD-208 ??
- ?? ?
- 460.4±45.0 °C(Predicted)
- ??
- 1.487
- ?? ??
- 2-8°C
- ???
- ? ??? DMSO: >5mg/mL
- ?? ?? (pKa)
- 4.56±0.26(Predicted)
- ??? ??
- ??
- ??
- ????? ?????
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
SD-208 C??? ??, ??, ??
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SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2???? ??
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1SD-208 ?? ?? ? ???
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SD-208 ?? ??
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|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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