LY-364947
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LY-364947 ??
- ???
- >230℃ (dec.)
- ?? ?
- 490.8±45.0 °C(Predicted)
- ??
- 1.283±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO: ???2mg/mL, ??
- ?? ?? (pKa)
- 8.94±0.50(Predicted)
- ??? ??
- ??
- ??
- ???? ????
- ???
- ?? 3?? ?? -20°? DMSO? ??
- InChIKey
- IBCXZJCWDGCXQT-UHFFFAOYSA-N
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T,N | ||
|---|---|---|---|
| ?? ???? ?? | 25-36/37/38-50/53 | ||
| ????? | 26-45-60-61 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| HS ?? | 2933491090 |
LY-364947 C??? ??, ??, ??
???? ??
Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T β R-I, ALK-5) (IC 50 values are 59, 400 and 1400 nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC 50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.LY-364947 ?? ?? ? ???
???
?? ??
LY-364947 ?? ??
???( 158)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29863 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22793 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 |
nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
LY-364947 ?? ??:
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