| Identification | More | [Name]
1-Tetralone | [CAS]
529-34-0 | [Synonyms]
1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE
1-TETRALONE
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE
3,4-DIHYDRO-1(2H)-NAPHTHALENONE
3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
ALPHA-TETRALONE
A-TETRALONE
KETOTETRAHYDRONAPHTHALENE
1(2H)-Naphthalenone
1,2,3,4-Tetrahydro-1-oxonaphthalene
1,2,3,4-Tetrahydronaphthalen-1-one
1-Oxo-1,2,3,4-tetrahydronaphthalene
1-Oxote-trahydronaphthalene
1-Oxotetralin
1-Tetrahydronathpalone
3,4-dihydro-1(2h)-naphthalenon
Tetralole
tetralone
1-Tetralone,97%
1(2H)-Naphthalenone, 3,4-dihydro- | [EINECS(EC#)]
208-460-6 | [Molecular Formula]
C10H10O | [MDL Number]
MFCD00001688 | [Molecular Weight]
146.19 | [MOL File]
529-34-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R20/22:Harmful by inhalation and if swallowed .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
QK4375000
| [TSCA ]
Yes | [HS Code ]
29143900 | [Hazardous Substances Data]
529-34-0(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Aluminum chloride-->Hydrogen fluoride-->Polyphosphoric acid-->Phosphorus pentoxide-->Tin tetrachloride-->Butyryl chloride-->Gamma Butyrolactone-->4-Phenylbutyric acid-->1,2,3,4-Tetrahydronaphthalene-->5-Ethyl-2-methylpyridine-->Chromic acetate-->1(2H)-Naphthalenone, 3,4-dihydro-, 2,2-dimethylhydrazone-->(4,4-Difluoro-3-buten-1-yl)benzene-->4-Phenylbutyryl chloride | [Preparation Products]
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid-->γ-Hydroxybutyrophenone-->7-Hydroxy-1-tetralone-->2,3-Dihydro-1,4-naphthoquinone-->(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol |
| Hazard Information | Back Directory | [Chemical Properties]
Clear amber to brown oily liquid | [Uses]
1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. | [Production Methods]
Intramolecular acylation of 4-phenylbutyric acid to 1,2,3,4-tetrahydronaphthalen-1-one (1-Tetralone).
 | [Synthesis Reference(s)]
Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8 | [Purification Methods]
Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.] |
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