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ChemicalBook--->CAS DataBase List--->171745-13-4

171745-13-4

171745-13-4 Structure

171745-13-4 Structure
IdentificationBack Directory
[Name]

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
[CAS]

171745-13-4
[Synonyms]

COMPOUND 56
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine
N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine
4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
[Molecular Formula]

C18H18BrN3O2
[MDL Number]

MFCD01074974
[MOL File]

171745-13-4.mol
[Molecular Weight]

388.26
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
[form ]

White to off-white powder.
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Warning
Hazard InformationBack Directory
[Uses]

Compound 56 is a potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor.
[Biological Activity]

compound 56, 4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (egfr) showing an ic50 of 0.006 nm. it competitively binds at the adenosine-triphosphate (atp) site of egfr. compound 56 is capable of inhibiting the phosphorylation of egf-dependent egfr, suppressing the proliferation and clonogenicity of a wide panel of egfr-overexpressing human cancer lines, and blocking egf-mediated mitogenesis and oncogenic transformation in fibroblasts overexpressing egfr. besides inhibiting egfr tyrosine kinase, it also inhibits the tyrosine kinase of human epidermal growth factor receptor 2 (her2/neu) but with a less potency.bridges aj, zhou h, cody dr, rewcastle gw, mcmichael a, showalter hd, fry dw, kraker aj, and denny wa. tyrosine kinase inhibitors. 8. an unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (pd 153035), a potent inhibitor of the epidermal growth factor receptor.j med chem 1966; 39 (1): 267-276monique bos, jhn mendelsohn, young-mee kim, joan albanell, david w. fry, and jose baelga. pd153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. clin cancer res 1997;3:2099-2106
[target]

EGFR
Spectrum DetailBack Directory
[Spectrum Detail]

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE(171745-13-4)MS
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