Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- synthesis
- Product Name:Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-
- CAS Number:190728-24-6
- Molecular formula:C17H14N2O5
- Molecular Weight:326.3
100-02-7
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35654-56-9
365 suppliers
$13.00/1g
144-55-8
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190728-24-6
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Yield:190728-24-6 89%
Steps:
48 Example 48
Example 48 (Reference Examples) 6,7-Dimethoxy-4-(4-nitrophenoxy)quinoline 4-Chloro-6,7-dimethoxyquinoline (1.84 g) and commercially available 4-nitrophenol (3.42 g) was mixed and stirred at 170° C. for 50 minutes. After cooling to room temperature in air, aqueous sodium hydrogen carbonate was added to the reaction mixture, and the admixture was extracted 3 times with ethyl acetate, and the ethyl acetate layer was washed with brine and then dried with anhydrous sodium sulfate. The solvent was removed by reduced-pressure distillation, and the resulting residue was purified by column chromatography on silica gel eluding with chloroform/methanol to obtain 4.54 g of the title compound (yield: 89%). 1 H-NMR (CDCl3, 500 MHz): δ 4.01 (s, 3H), 4.06 (s, 3H), 6.69 (d, J=4.9 Hz, 1H), 7.27 (d, J=9.1 Hz, 2H), 7.37 (s, 1H), 7.47 (s, 1H), 8.32 (d, J=9.1 Hz, 2H), 8.62 (d, J=4.9 Hz, 1H) Mass spectrometry data (FD-MS, m/z): 326 (M+)
References:
US6143764,2000,A
13425-93-9
274 suppliers
$6.00/1g
350-46-9
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$10.60/1gm:
190728-24-6
33 suppliers
inquiry
35654-56-9
365 suppliers
$13.00/1g
190728-24-6
33 suppliers
inquiry
13425-93-9
274 suppliers
$6.00/1g
190728-24-6
33 suppliers
inquiry