1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- synthesis
- Product Name:1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl-
- CAS Number:849221-94-9
- Molecular formula:C28H25N3O5
- Molecular Weight:483.52
![Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-](/CAS/20150408/GIF/145591-80-6.gif)
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Yield:-
Reaction Conditions:
Stage #1: 1-(phenylcarbamoyl)cyclopropane-1-carboxylic acidwith 2-(6-chloro-1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide; for 0.333333 h;
Stage #2: 4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline in N,N-dimethyl-formamide at 35; for 3 h;Molecular sieve;
Steps:
4
Add DMF, HCTU, and DIEA to the reaction flask at room temperature, and stir for 10 minutes. After adding Zhong 1 and stirring for another 20 minutes, then adding Zhong 2 again. After 3 hours of reaction, 14% of the raw material remained, and the temperature was raised to 35°C until the reaction was complete. Add 10L of water,The product is separated out and filtered to obtain the defluorinated impurity of cabozantinib with a purity of 99%. Among them, Intermediate 1: 334.5g; Intermediate 2: 400g; HCTU: 620g; DIEA: 387.7g; DMF (molecular sieve drying): 3.4L.
References:
CN111533690,2020,A Location in patent:Paragraph 0019; 0037-0038
190728-25-7
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![Cyclopropanecarbonyl chloride, 1-[(phenylamino)carbonyl]-](/CAS/20210305/GIF/1345847-75-7.gif)
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598-10-7
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