ChemicalBook CAS DataBase List PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)-

PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)- synthesis

5synthesis methods

Product Name:PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)-
CAS Number:84611-43-8
Molecular formula:C12H10ClNO
Molecular Weight:219.67

41288-96-4

100-39-0

84611-43-8

The reaction was carried out with 2-chloro-5-hydroxypyridine (6-chloropyridin-3-ol, 1.0 g) and benzyl bromide (benzyl bromide, 1.5 g) as raw materials in the presence of potassium carbonate (2.4 g) at 60 °C for 18 h with stirring in N,N-dimethylformamide (DMF, 40 mL). After completion of the reaction, the reaction mixture was filtered and the solvent in the filtrate was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford the target compound 2-chloro-5-benzyloxypyridine (3-(benzyloxy)-2-chloro pyridine, 1.3 g) in quantitative yield.

41288-96-4 Synthesis

41288-96-4
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100-39-0
438 suppliers
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84611-43-8
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$45.00/50mg

Yield:84611-43-8 100%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60; for 18 h;

Steps:

166-1 (166-1) Synthesis of 5- (benzyloxy) -2-chloropyridine (Compound 166-1)

6-chloropyridin-3-ol (1.0 g),Benzyl bromide (1.5 g) and potassium carbonate (2.4 g)Was dissolved in DMF (40 mL) and stirred at 60 ° C. for 18 hours.After filtering the reaction solution,The solvent of the obtained filtrate was distilled off under reduced pressure to obtain a residue,Purification by silica gel column chromatography (hexane-ethyl acetate)5- (benzyloxy) -2-chloropyridine1.3 g (yield quant.) Was obtained.

References:

JP2017/171619,2017,A Location in patent:Paragraph 0233; 0235

41288-96-4 Synthesis

41288-96-4
341 suppliers
$8.00/1g

100-44-7 Synthesis