DICLOFENAC METHYL ESTER synthesis
- Product Name:DICLOFENAC METHYL ESTER
- CAS Number:15307-78-5
- Molecular formula:C15H13Cl2NO2
- Molecular Weight:310.18
67-56-1
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$7.29/5ml-f
15307-86-5
377 suppliers
$48.00/25g
15307-78-5
97 suppliers
$35.00/10mg
Yield: 96%
Reaction Conditions:
with sulfuric acid for 0.25 h;Reflux;
Steps:
3.1.4.2. Diclofenac Methyl Ester (2)
Diclofenac acid (5 g) was dissolved in methanol (80 mL)with stirring and sulfuric acid (3 mL) was added drop wisewith continuous stirring and the mixture was heated underreflux for 15 min. After completion of the reaction (TLCanalysis), it was cooled to room temperature and poured ontocrushed ice (250 g) to obtain crystalline solid (2) which wasfiltered, washed with water followed by 5% sodium hydrogencarbonate solution, finally with water and dried in air.
References:
Shah, Shazia;Arshia;Kazmi, Nida Siraj;Jabeen, Almas;Khan, Khalid Mohammed;Raza, Abeer;Faheem, Aisha;Dastagir, Nida;Ahmed, Tariq;Ahmed, Shakil;Perveen, Shahnaz [Medicinal Chemistry,2018,vol. 14,# 7,p. 674 - 687]
57486-69-8
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$6.00/1g
608-31-1
314 suppliers
$12.00/25g
15307-78-5
97 suppliers
$35.00/10mg
66370-75-0
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608-31-1
314 suppliers
$12.00/25g
15307-78-5
97 suppliers
$35.00/10mg
15307-79-6
883 suppliers
$14.00/5g
74-88-4
351 suppliers
$15.00/10g
15307-78-5
97 suppliers
$35.00/10mg
15307-86-5
377 suppliers
$48.00/25g
18107-18-1
212 suppliers
$33.00/5g
15307-78-5
97 suppliers
$35.00/10mg