Methyl 2-(2-iodophenyl)acetate synthesis
- Product Name:Methyl 2-(2-iodophenyl)acetate
- CAS Number:66370-75-0
- Molecular formula:C9H9IO2
- Molecular Weight:276.07
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Yield: 100%
Reaction Conditions:
in methanol;diethyl ether;dichloromethane at 0; for 1 h;
Steps:
23
Methyl(2-iodophenyl)acetate (23- 1). Trimethylsilyl diazomethane (15.3 ml, 30.6 mmol, 2.0 M in diethyl ether) was added dropwise to a stirred, cooled O0C solution of (2-iodophenyl)acetic acid (4.0 g, 15.3 mmol) and MeOH (10 ml) in CH2CI2 (50 ml) and the solution was stirred at 0 0C for 1 hour. The yellow solution was purged with nitrogen for 10 minutes. The solvent removed in vacuo and the residue was azeotroped with THF (3 x 25 ml) to afford 4.2 g, 100 % of 23-l as a yellow oil.
References:
MERCK & CO., INC. WO2008/51532, 2008, A1 Location in patent:Page/Page column 46
67-56-1
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18698-96-9
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66370-75-0
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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