天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Capmatinib
1029712-80-8

Capmatinib synthesis

9synthesis methods
-

Yield:1029712-80-8 90%

Reaction Conditions:

Stage #1: 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamidewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 5; for 0.5 h;
Stage #2: dimethyl sulfate in N,N-dimethyl-formamide;mineral oil at 60; for 2 h;

Steps:

1.2 Step 2: Preparation of camatinib

Add DMF 500ml, 20.0g (0.05mol) of formula II compound to a 2L reaction flask, stir to dissolve, cool to 0-5°C, add 2.4g (0.06mol) 60% sodium hydride in mineral oil in batches, and complete the addition, Stirring for 0.5 hours, adding 7.5 g (0.06 mol) of dimethyl sulfate dropwise, after dropping, slowly increasing to 60° C. and reacting for 2 hours. After the reaction is complete, add dilute hydrochloric acid dropwise to quench, concentrate under reduced pressure to remove part of the solvent, pour into water, extract with ethyl acetate, adjust the aqueous phase to alkaline, extract with ethyl acetate, wash with water, concentrate the organic phase to obtain 18.6 g of yellow solid, it is the title compound, the yield is 90%, and the HPLC purity is 99.5%.

References:

CN111825678,2020,A Location in patent:Paragraph 0034-0035; 0038-0039

1029714-87-1 Synthesis
2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile

1029714-87-1
15 suppliers
inquiry

Capmatinib Related Search: