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ChemicalBook CAS DataBase List Bromothymol Blue
76-59-5

Bromothymol Blue synthesis

2synthesis methods
Bromothymol Blue is a pH indicator used for the determination of weak acids and bases. It is yellow when it is acidic and blue when it is alkaline. Under stirring, bromine is added into the glacial acetic acid suspension of thymol blue, and the reaction is carried out at 50 °C to obtain bromothymol blue.
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: zinc chloride / 100 - 110 °C
2: glacial acetic acid; bromine

References:

Lubs;Clark [Journal. Washington Academy of Sciences, Washington, D. C,vol. 6,p. 482][Chemisches Zentralblatt,1916,vol. 87,# II,p. 1068]

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