天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
571-55-1

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate synthesis

3synthesis methods
Triethyl orthoformate

122-51-0

Ethyl 4,4,4-trifluoroacetoacetate

372-31-6

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate

571-55-1

General procedure for the synthesis of ethyl ethoxy-2-methylene trifluoroacetoacetate from triethyl orthoformate and ethyl trifluoroacetoacetate: ethyl 4,4,4-trifluoro-3-oxobutanoate (30 g, 162.9 mmol) was added to a solution of acetic anhydride (50 mL) containing triethoxymethane (72.4 g, 488.8 mmol). The reaction mixture was stirred continuously at 135 °C for 18 hours. Upon completion of the reaction, the brown mixture was concentrated to afford ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (38 g, 97.1% yield), the product was a brown oil that could be used in subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.23-1.33 (m, 3H), 1.40 (dt, J = 14.18, 7.19 Hz, 3H), 4.19-4.36 (m, 4H), 7.66-7.87 (m, 1H).

-

Yield:571-55-1 97.1%

Reaction Conditions:

with acetic anhydride at 135; for 18 h;

Steps:

1.E E.
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate, 1f

Ethyl 4,4,4-trifluoro-3-oxobutanoate (30 g, 162.9 mmol) was added to a solution of triethoxymethane (72.4 g, 488.8 mmol) in acetic anhydride (50 mL).
The mixture was stirred at 135° C. for 18 h.
The brown mixture was concentrated to afford ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate, 1f (38 g, 97.1%) as a brown oil, which was used in the following reaction without further purification. 1H NMR (400 MHz, CDCl3) δ ppm 1.23-1.33 (m, 3H) 1.40 (dt, J=14.18, 7.19 Hz, 3H) 4.19-4.36 (m, 4H) 7.66-7.87 (m, 1H).

References:

US2018/170909,2018,A1 Location in patent:Paragraph 0824; 0825

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Related Search: