4-AMINOPYRIDAZINE synthesis
- Product Name:4-AMINOPYRIDAZINE
- CAS Number:20744-39-2
- Molecular formula:C4H5N3
- Molecular Weight:95.1
823-58-5
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$9.00/1g
20744-39-2
176 suppliers
$15.00/250mg
Yield:20744-39-2 100%
Reaction Conditions:
with sodium hydroxide;hydrogen;palladium 10% on activated carbon in tetrahydrofuran;water at 20; for 48 h;
Steps:
151.1
Example 151; 4-(3-Phenyl-1,2,4-thiadiazol-5-yl)-N-pyridazin-4-ylpiperazine-1-carboxamide; (1) Pyridazine-4-amine; A mixture of 3,6-dichloropyridazine-4-amine (5.00 g, 18.2 mmol), tetrahydrofuran (100 ml), sodium hydroxide (8.00 g, 200 mmol), water (32 ml) and 10% palladium-carbon (500 mg) was stirred under a hydrogen atmosphere at room temperature for 2 days, insolubles were filtered off and the filtrate was concentrated. The residue was dissolved in methanol (100 ml), insolubles were filtered off and the filtrate was concentrated to obtain the desired product quantitatively as a solid. 1H-NMR (DMSO-d6) δ; 2.51 (2H, br s), 6.00 (1H, br s), 7.81 - 7.85 (1H, m), 7.98 - 8.00 (1H, m).
References:
EP1813606,2007,A1 Location in patent:Page/Page column 83-84
14161-11-6
150 suppliers
$9.00/1g
20744-39-2
176 suppliers
$15.00/250mg
289-80-5
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$6.00/1g
20744-39-2
176 suppliers
$15.00/250mg
53180-76-0
85 suppliers
$61.00/100mg
20744-39-2
176 suppliers
$15.00/250mg
89180-50-7
62 suppliers
$39.00/100mg
20744-39-2
176 suppliers
$15.00/250mg