5,6-dichloropyridazin-4-amine synthesis
- Product Name:5,6-dichloropyridazin-4-amine
- CAS Number:89180-50-7
- Molecular formula:C4H3Cl2N3
- Molecular Weight:163.99
14161-11-6
150 suppliers
$9.00/1g
89180-50-7
62 suppliers
$39.00/100mg
Yield: 25%
Reaction Conditions:
with ammonia in tetrahydrofuran at 125; for 5 h;Sealed tube;
Steps:
18.2 Step 2) 5,6-dichloropyridazin-4-amine
A mixture of 3,4,5-trichloropyridazine (17.79 g, 96.99 mmol) and a solution of NH3 in THF ( 250 mL, 750 mmol, 3 M) was stirred at 125 °C in a sealed tube for 5 h. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/2) to give the title compound as a white solid (4.01 g, yield 25%).MS (ESI, pos. ion) m/z: 164.1 [M+H]+;1H NMR (600 MHz, CDCb) d (ppm): 8.60 (s, 1H), 4.89 (s, 2H).
References:
SUNSHINE LAKE PHARMA CO., LTD.;CALITOR SCIENCES, LLC;XI, Ning;LI, Minxiong;PENG, Ju;LI, Xiaobo;ZHANG, Tao;HU, Haiyang;CHEN, Wuhong;BAI, Changlin;KE, Donghua;CHEN, Peng WO2019/99311, 2019, A1 Location in patent:Paragraph 000420
14161-11-6
150 suppliers
$9.00/1g
89180-50-7
62 suppliers
$39.00/100mg
53180-76-0
85 suppliers
$61.00/100mg
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89180-50-7
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$39.00/100mg
6339-19-1
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$40.00/10 mg
89180-50-7
62 suppliers
$39.00/100mg
14161-11-6
150 suppliers
$9.00/1g
7664-41-7
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$15.00/100ml
89180-50-7
62 suppliers
$39.00/100mg
53180-76-0
85 suppliers
$61.00/100mg