ChemicalBook CAS DataBase List 2-Chloro-4,5-difluorobenzoic acid

2-Chloro-4,5-difluorobenzoic acid synthesis

8synthesis methods

Product Name:2-Chloro-4,5-difluorobenzoic acid
CAS Number:110877-64-0
Molecular formula:C7H3ClF2O2
Molecular Weight:192.55

121872-94-4

110877-64-0

Example 2 Preparation of 2-chloro-4,5-difluorobenzoic acid: 280.4 g (0.4 mol) of 12% sodium hypochlorite aqueous solution was added to 19.1 g (0.1 mol) of 1-(2-chloro-4,5-difluorophenyl)ethanone. The reaction mixture was stirred under reflux conditions for 4 hours. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted slowly and dropwise with concentrated hydrochloric acid to 1. The precipitated white crystals were dissolved with dichloromethane and the organic and aqueous phases were separated. The aqueous phase was extracted twice with dichloromethane and the organic phases were combined. The solvent was removed by distillation to give 16.4 g (yield: 85.1%) of 2-chloro-4,5-difluorobenzoic acid as white crystals.

121872-94-4
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$15.00/5g

110877-64-0
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$5.00/1g

Yield:110877-64-0 85.1%

Reaction Conditions:

with hydrogenchloride;sodium hypochlorite in dichloromethane;

Steps:

2 Preparation of 2-chloro-4,5-difluorobenzoic acid

EXAMPLE 2 Preparation of 2-chloro-4,5-difluorobenzoic acid To 19.1 g (0.1 mol) of 2-chloro-4,5-difluoroacetophenone, 280.4 g (0.4 mol) of a 12% sodium hypochlorite aqueous solution was added, and the mixture was reacted under reflux for 4 hours. After cooling, concentrated hydrochloric acid was dropwise added thereto until the pH became 1. The formed white crystals were dissolved in methylene chloride and separated from the aqueous phase. The separated aqueous phase was extracted twice with methylene chloride, and the extracts were added to the oil phase. Then, the solvent was distilled off to obtain 16.4 g (yield: 85.1%) of 2-chloro-4,5-difluorobenzoic acid as white crystal.

References:

US4994610,1991,A

83506-93-8 Synthesis