Cefquinome sulfate whose trade name gram hundred spies (Cobactan), is the forth generation animal specific cephalosporins that German Hirst company (Hoechst AG) developed the eighties in 20th century.Because cefquinome is very low at gastral absorbance, be usually made into the form of sulfate clinically. It is only used in veterinary applications.

Classification

Cefquinome sulfate is a fourth-generation cephalosporin with pharmacological and antibacterial properties.

Uses

Cefquinome sulfate is used for the treatment of bacterial infections in cattle and pigs caused by the Gram positive and Gram negative micro organisms sensitive to cefquinome.

Mechanism of action

Cefquinome sulfate interferes with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to bacterial cell lysis and death. Although resistance to cefquinome is rare, they are active against bacteria carrying the AmpC-type β-lactamase resistance mechanism.

Side effects

Use of Cefquinome sulfate may result in localized tissue reaction. Tissue lesions are repaired 15 days after the last administration of the product.

FDA guidelines

Administered products will be used in individual animals for short duration and by prescription only. The extent of use is ranked low. Avoid human drug resistance to fourth-generation cephalosporins by authorizing extra-label prohibition.