Product Name:    Trimethoprim

Synonyms:    methoxybenzyl aminopyrimidine;Trimethopim(TMP);TRIMETHOPRIM, CRYSTALLIZED;TRIMETHOPRIM VETRANAL, 250 MG;5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine;Antibiotic synergist;trimethoprim crystalline;TRIMETHOPRIM BP

CAS:    738-70-5

MF:    C14H18N4O3

MW:    290.32

EINECS:    212-006-2

Product Categories:    Thiophenes;Pharmaceutical;TRIMPEX;antibiotic;Broad-spectrum antibacterials;API;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics;738-70-5

Trimethoprim selectivity between bacterial and mammalian dihydrofolate reductases results from the subtle but significant architectural differences between these enzyme systems. Whereas the bacterial enzyme and the mammalian enzyme both efficiently catalyze the conversion of dihydrofolic acid to tetrahydrofolic acid, the bacterial enzyme is sensitive to inhibition by trimethoprim by up to 40,000-fold lower concentrations than the mouse enzyme is. This difference explains the useful selective toxicity of trimethoprim.