Description of Promestriene from Wuhan Fortuna Chemical Co.,Ltd

Specifications(COA) of Promestriene CAS 39219-28-8

Introduction of Promestriene is a synthetic, topically applied estrogen analog used to treat genitourinary symptoms of menopause (e.g., vaginal dryness, atrophy, painful intercourse). Unlike systemic estrogens, it acts locally on vaginal tissues, stimulating epithelial growth, improving lubrication, and restoring pH balance with minimal systemic absorption, reducing risks like thrombosis or hormonal cancers. Administered as a vaginal cream or ovule (e.g., Colpotrophine?), it’s prescribed for postmenopausal women with vulvovaginal atrophy. Its low systemic exposure makes it safer for those avoiding hormone replacement therapy. Not FDA-approved but available in Europe and Latin America. Contraindicated in estrogen-sensitive cancers. Consult a healthcare provider for use.

Application of Promestriene is a synthetic, topically applied estrogen analog primarily used in gynecological treatments. Here's a detailed overview:

Chemical Structure

Core Structure: A synthetic steroid derivative structurally related to estradiol (a natural estrogen).

Contains a 3-methyl ether group at position 3 (distinguishing it from estradiol).

Molecular Formula: C??H??O?.

Molecular Weight: 286.4 g/mol.

Properties

Mechanism: Acts as a local estrogen receptor agonist, binding to estrogen receptors in vaginal and vulvar tissues.

Absorption: Minimal systemic absorption when applied topically, reducing systemic estrogenic effects.

Solubility: Formulated in creams or vaginal ovules for localized delivery.

Applications

1.     Primary Use:

Treatment of Genitourinary Syndrome of Menopause (GSM):

Addresses symptoms like vaginal dryness, atrophy, dyspareunia (painful intercourse), and urinary discomfort.

Postmenopausal Vulvovaginal Atrophy: Restores epithelial thickness and lubrication.

2.     Advantages Over Systemic Estrogens:

Minimizes systemic exposure, lowering risks of endometrial hyperplasia, thrombosis, or breast cancer associated with oral/hormonal therapies.

Mechanism of Action

Local Estrogenic Activity:

Binds to estrogen receptors in vaginal mucosa, stimulating glycogen production, epithelial proliferation, and blood flow.

Enhances vaginal elasticity, pH normalization, and lubrication.

Formulations & Administration

Topical Cream/Ovules: Applied intravaginally (e.g., 1–2 times weekly).

Brand Names: Marketed as Colpotrophine? (common in Europe and Latin America).

Safety & Side Effects

Common Side Effects: Local irritation, itching, or burning (rare).

Systemic Risks: Very low due to minimal absorption; no significant impact on serum estrogen levels.

Contraindications:

Estrogen-sensitive cancers (e.g., breast or endometrial cancer).

Undiagnosed vaginal bleeding.

Regulatory Status

Approved: In Europe, Latin America, and parts of Asia; not FDA-approved in the U.S.

Prescription Requirement: Yes.

Key Advantages

Targeted relief for urogenital atrophy without systemic hormonal risks.

Well-tolerated in patients contraindicated for systemic hormone replacement therapy (HRT).

Promestriene is a niche but valuable option for managing menopausal urogenital symptoms, prioritizing localized efficacy and safety. Always consult a healthcare provider for personalized use.

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is  the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Promestriene with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Promestriene.