
2-METHOXYESTRADIOL
Price | $540 |
Package | 100gram |
Min. Order: | 100gram |
Supply Ability: | 20 tons |
Update Time: | 2024-09-25 |
Product Details
Product Name: 2-METHOXYESTRADIOL | CAS No.: 362-07-2 |
Min. Order: 100gram | Purity: 99% HPLC |
Supply Ability: 20 tons | Release date: 2024/09/25 |
CAS:362-07-2
MF: C19H26O3
MW:302.41
Melting Point:188-190°C
Boiling Point:464.4±45.0 °C(Predicted)
Density:1.178±0.06 g/cm3(Predicted)
Product Description
2-methoxyestradiol (2-methoxyestradiol), 2-methoxyestradiol (2ME2) was first found in the urine of pregnant women, and it was previously believed to be the end product of estradiol metabolism. not much. Laboratory data indicate that 2-methoxyestradiol is a substrate of P450CYP1A2, especially CYP3A4; it is also extensively metabolized by uridine diphosphate glucuronyltransferase (UDP-glucuChemicalbookronosyltransferase). CYP1A2, CYP3A4, and uridine diphosphate glucuronyltransferase are widely present in the duodenum, small intestine, and liver, but these enzymes are less distributed in the large intestine. Therefore, oral 2-methoxyestradiol must be released as far as possible in the large intestine, so that more of the absorbed part can enter the systemic circulation. Therefore, it is very urgent to study to improve the druggability of 2-methoxyestradiol.
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