- 2-METHOXYESTRADIOL
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- $0.00 / 25KG
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2025-05-16
- CAS:362-07-2
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20TON
- 2-Methoxyestradiol
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- $0.00 / 1kg
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2025-05-16
- CAS:362-07-2
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 1000kg
- 2-Methoxyestradiol
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- $0.00 / 1kg
-
2025-05-16
- CAS:362-07-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 650KG
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| | 2-METHOXYESTRADIOL Basic information |
| Product Name: | 2-METHOXYESTRADIOL | | Synonyms: | 2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS;2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL;2-Hydroxyestradiol 2-Methyl Ether;2-Methoxy-17b-estradiol;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem;2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | | CAS: | 362-07-2 | | MF: | C19H26O3 | | MW: | 302.41 | | EINECS: | 263-807-9 | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Inhibitor;Inhibitors;2-ME2;Isolabel;APIs | | Mol File: | 362-07-2.mol |  |
| | 2-METHOXYESTRADIOL Chemical Properties |
| Melting point | 188-190°C | | Boiling point | 464.4±45.0 °C(Predicted) | | density | 1.178±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: 10 mg/mL | | form | crystalline | | pka | 10.29±0.60(Predicted) | | color | light yellow | | λmax | 286nm(EtOH)(lit.) | | InChI | InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/s3 | | InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N | | SMILES | C[C@@]12[C@H](CC[C@@]1([H])[C@]1([H])CCC3C=C(O)C(OC)=CC=3[C@@]1([H])CC2)O |&1:1,2,5,7,20,r| | | CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| | 2-METHOXYESTRADIOL Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. | | Uses | A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a | | Uses | A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly | | Uses | 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine
binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. | | Uses | 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity. | | Definition | ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. | | Biological Activity | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. | | in vivo | To investigate the effect of 2-Methoxyestradiol (2-ME2) on uveitis development, C57BL/6 mice are randomly assigned into two groups and immunized with IRBP peptide. 2ME2 group starts 2-Methoxyestradiol (15 mg/kg) intraperitoneally from day 0 to day 13 while control group is given with vehicle. The disease score of 2-Methoxyestradiol (2ME2) group is 0.30±0.30, significantly lower than that of control group 2.09±0.28 (p<0.05), each group containing 5 mice[3].
Treatment with 2-Methoxyestradiol (60-600 mg/kg/d) results in a dose-dependent inhibition of tumor growth. The percentage of cells with strong pimonidazole-positive staining (+++) is significantly decreased in the 2-Methoxyestradiol-treated group (36.0% for 60 mg/kg/d and 0% for 200 and 600 mg/kg/d) compare with the vehicle-treated group (86.5%). This may be attributed to the dramatic inhibition of tumor growth in a dose-dependent manner following 2-Methoxyestradiol treatment[4]. | | IC 50 | Human Endogenous Metabolite |
| | 2-METHOXYESTRADIOL Preparation Products And Raw materials |
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