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| ZM 323881 hydrochloride Basic information |
Product Name: | ZM 323881 hydrochloride | Synonyms: | Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1);ZM 323881 HCl, >=99%;ZM 323881 hydrochloride USP/EP/BP;ZM323881 hydrochloride HCL ZM-323881;ZM 323881 hydrochloride|||ZM 323881 HCl;ZM323881 hydrochloride, 10 mM in DMSO | CAS: | 193000-39-4 | MF: | C22H19ClFN3O2 | MW: | 411.86 | EINECS: | | Product Categories: | Inhibitors | Mol File: | 193000-39-4.mol |  |
| ZM 323881 hydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | form | Powder | color | Light yellow to yellow |
| ZM 323881 hydrochloride Usage And Synthesis |
Uses | Hydrochloride salt of ZM 323881, a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with application towards cancer treatments. | Definition | ChEBI: ZM 323881 hydrochloride is a hydrochloride obtained by combining ZM 323881 with one molar equivalent of hydrochloric acid. It has a role as a vascular endothelial growth factor receptor antagonist and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It contains a ZM 323881(1+). | Biological Activity | ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.', 'ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR). | storage | Desiccate at +4°C |
| ZM 323881 hydrochloride Preparation Products And Raw materials |
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