- 6-Nitro-1H-indazole
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- $0.00 / 25kg
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2025-04-21
- CAS:7597-18-4
- Min. Order: 1kg
- Purity: ≥98% by HPLC
- Supply Ability: 100kg/month
- 6-Nitroindazole
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- $0.00 / 1g
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2025-01-03
- CAS:7597-18-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 2000tons
- 6-Nitroindazole
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- $0.00/ kg
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2024-11-26
- CAS:7597-18-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1 ton
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| | 6-Nitroindazole Basic information |
| | 6-Nitroindazole Chemical Properties |
| | 6-Nitroindazole Usage And Synthesis |
| Description | 6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].
| | Chemical Properties | yellow powder | | Uses | Anticonvulsant. | | Synthesis | 6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated acetonitrile. | | References | [1] HERRAIZTOMAS GuillénHugo AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170. |
| | 6-Nitroindazole Preparation Products And Raw materials |
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