ML193
| 中文名稱 | ML193 |
|---|---|
| 中文同義詞 | N-(4-(N-(3,4-二甲基異惡唑-5-基)氨磺?；?苯基)-6,8-二甲基-2-(吡啶-2-基)喹啉-4-甲酰胺;ML 193,GPR55拮抗劑;N-(4-(N-(3,4-二甲基異噁唑-5-基)胺磺?；?苯基)-6,8-二甲基-2-(吡啶-2-基)喹啉-4-甲酰胺;ML193,10 MM DMSO 溶液 |
| 英文名稱 | ML193 |
| 英文同義詞 | ML193;N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-;ML193 trifluoroacetate >=98% (HPLC);N-(4-(N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl)phenyl)-6,8-dimethyl-2-(pyridin-2-yl)quinoline-4-carboxamide;CID 1261822;Inhibitor,deficits,motor,sensorimotor,CID-1261822,G protein-coupled receptor 55,disease,ML-193,Parkinson,ML193,CID1261822,ML 193,inhibit,GPR55;ML-193, 10 mM in DMSO |
| CAS號 | 713121-80-3 |
| 分子式 | C28H25N5O4S |
| 分子量 | 527.59 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 713121-80-3.mol |
| 結(jié)構(gòu)式 |  |
ML193 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 乙醇中≤0.1mg/ml；DMSO中≤2mg/ml；二甲基甲酰胺中≤3mg/ml |
| 形態(tài) | 結(jié)晶固體 |
| 顏色 | 米白色至黃色 |
IC50: 221 nM (GPR55)
ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC
50
s of 0.22 μM and 0.12 μM, respectively.
ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC
50
of 0.2 μM in U2OS cells.
ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates.
ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation.
ML193 (1 and 5 μg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats.
| Animal Model: | Male Wistar rats (200-250 g) were induced experimental Parkinson by 6-hydroxydopamine (6-OHDA, 10 μg/rat) |
| Dosage: | 1 and 5 μg/rat |
| Administration: | Injected into the right striatum at a rate of 1 μL/min |
| Result: | Increased the time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-110125 | ML-193 | 713121-80-3 | 1 mg | 300元 |
| 2025/05/22 | HY-110125 | ML193 ML-193 | 713121-80-3 | 5mg | 600元 |