CPD1578
| 中文名稱 | CPD1578 |
|---|---|
| 中文同義詞 | 7-(間甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺;化合物CU-CPT-8M;化合物CU-CPT-8M,10 MM DMSO 溶液;CU-CPT-8m ,S4461 |
| 英文名稱 | CU-CPT-8m |
| 英文同義詞 | CPD1578;CU-CPT-8m;cas 125079-83-6;CU-CPT-8M;CAS 125079-83-6 ;TLR8 INHIBITOR;TLR8-specific antagonist;7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-;CU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor |
| CAS號 | 125079-83-6 |
| 分子式 | C14H12N4O |
| 分子量 | 252.27 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 125079-83-6.mol |
| 結(jié)構(gòu)式 |  |
CPD1578 性質(zhì)
| 密度 | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 氯仿：5mg/mL； DMF：0.2mg/mL； DMSO：0.2mg/mL；乙醇：微溶 |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 12.41±0.50(Predicted) |
| 顏色 | 白色至米白色 |
| InChI | InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19) |
| InChIKey | HNKGGVGQAVODNJ-UHFFFAOYSA-N |
| SMILES | C12=C(C(N)=O)C=NN1C(C1=CC=CC(C)=C1)=CC=N2 |
|
TLR8 67 nM (IC 50 ) |
CU-CPT-8m is a specific TLR8 antagonist, with an IC 50 of 67±10 nM and negligible cytotoxicity. The K d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC 50 of 90±10 nM, which is in good agreement with its IC 50 value determined in HEK-Blue TLR8 cells.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-112050 | CU-CPT-8m | 125079-83-6 | 1 mg | 502元 |
| 2025/05/22 | HY-112050 | CPD1578 CU-CPT-8m | 125079-83-6 | 5mg | 1000元 |