鹽酸維那卡蘭
中文名稱 | 鹽酸維那卡蘭 |
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中文同義詞 | 鹽酸維那卡蘭;鹽酸弗納卡蘭;鹽酸維納卡蘭;化合物 T17227;(R)-1-((1R,2R)-2-(3,4-二甲氧基苯乙氧基)環(huán)己基)吡咯烷-3-醇鹽酸鹽;鹽酸維那卡蘭,10 MM DMSO 溶液 |
英文名稱 | VERNAKALANT HYDROCHLORIDE |
英文同義詞 | RSD 1235 hydrochloride;RSD1235 hydrochloride;RSD-1235 hydrochloride;Vernakalant ((3R,1'R,2'R)-Isomer) HCl;Vernakalant HCl;VERNAKALANT HYDROCHLORIDE;D06665;Vernakalant hydrochloride (usan) |
CAS號 | 748810-28-8 |
分子式 | C20H32ClNO4 |
分子量 | 385.93 |
EINECS號 | |
相關(guān)類別 | |
Mol文件 | 748810-28-8.mol |
結(jié)構(gòu)式 | ![]() |
鹽酸維那卡蘭 性質(zhì)
熔點 | 151-153oC |
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儲存條件 | Hygroscopic, Refrigerator, under inert atmosphere |
溶解度 | 可溶于DMSO(少許)、甲醇(少許) |
形態(tài) | 固體 |
顏色 | 白色至淺黃色 |
IC50: 13.35±0.93 μM (Kv1.5 channel wt ), 0.61±0.03 μM ( I508F ), 1.63±0.09 μM (Kv1.5 channel T479A )
Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC 50 of 329±19 μM (n=4-10), compared with a control IC 50 of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC 50 for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.
安全信息
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2025/05/22 | HY-14183 | 鹽酸維那卡蘭 Vernakalant Hydrochloride | 748810-28-8 | 1 mg | 600元 |
2025/05/22 | HY-14183 | 鹽酸維那卡蘭 Vernakalant Hydrochloride | 748810-28-8 | 2mg | 950元 |