離子霉素
| 中文名稱 | 離子霉素 |
|---|---|
| 中文同義詞 | 羅紅霉素(游離酸)(鏈霉菌屬載體);離子霉素;離子霉素, 來源于鏈霉菌;離子霉素(乙醇溶液);來自共生鏈霉菌的IONOMYCIN;IONOMYCIN游離態(tài);碘霉素;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羥基-22-((2S,2'R,5S,5'S)-5'-((R)-1-羥乙基)-2,5'-二甲基八氫-[2,2'-聯(lián)呋喃]-5-基)-4,6,8,12,14,18,20-七甲基-9-氧代二十二烷-10,16-二烯酸 |
| 英文名稱 | IONOMYCIN |
| 英文同義詞 | (4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt;SQ-23377;Ionomycin,Free Acid,from Streptomyces conglbatus;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid;SQ 23377, EM 94;Ionomycin, free acid, from Streptomyces conglobatus;(4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid;ionomycin calcium salt from streptomyces conglobatus |
| CAS號 | 56092-81-0 |
| 分子式 | C41H72O9 |
| 分子量 | 709.01 |
| EINECS號 | |
| 相關(guān)類別 | 抗生素;微生物代謝物;醫(yī)藥原料;試劑盒-細(xì)胞分析試劑盒;抗體;MiscellaneousMore...Close...;A - KResearch Essentials;Antibacterial;Antibiotics A to;Antibiotics by Application;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Calcium channel;Ion Channels;antibiotic;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Spectrum of Activity |
| Mol文件 | 56092-81-0.mol |
| 結(jié)構(gòu)式 |  |
離子霉素 性質(zhì)
| 沸點 | 817.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.072±0.06 g/cm3(Predicted) |
| 儲存條件 | −20°C |
| 溶解度 | 在乙醇中水中的溶解度為至10mM，在DMSO中水中的溶解度為至10mM。 |
| 形態(tài) | 蠟狀固體 |
| 酸度系數(shù)(pKa) | 4.77±0.10(Predicted) |
| 顏色 | 粘黃色 |
| BRN | 3642126 |
| 穩(wěn)定性 | 可在-20°下的DMSO或乙醇溶液保存長達(dá)3個月。 |
Calcium ionophore
Ionomycin is a Calcium ionophore and an antibiotic produced by
Streptomyces conglobatus
.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca
2+
concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.
安全信息
| 危險品標(biāo)志 | Xn,Xi |
|---|---|
| 危險類別碼 | 22-36/37/38 |
| 安全說明 | 36-36/37/39-27-26-24/25 |
| WGK Germany | 3 |
| RTECS號 | NO0650000 |
| F | 8-10 |
| 危險等級 | 3 |
| 海關(guān)編碼 | 29419090 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-13434 | 離子霉素 Ionomycin | 56092-81-0 | 1mg(14.1mM * 100μL in Ethanol) | 1450元 |
| 2025/02/08 | HY-13434 | 離子霉素 Ionomycin | 56092-81-0 | 5mg(14.1mM * 500μL in Ethanol) | 3900元 |