印枳堿
| 中文名稱 | 印枳堿 |
|---|---|
| 中文同義詞 | 印枳堿;N-[2-羥基-2-(4-甲氧基苯基)乙基]肉桂酰胺;印枳堿,10 MM DMSO 溶液 |
| 英文名稱 | Aegelin |
| 英文同義詞 | N-(2-Hydroxy-2-(4-Methoxyphenyl)ethyl)cinnaMaMide;Aegeline;Aegeline,N-[2-hydroxy-2(4-Methoxyphenyl) ethyl]-3-phenyl-2-propenaMide;Aegelin;(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide;2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-;(E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide;N-Cinnamoyl-β-hydroxy-4-methoxyphenyl-aethylamin |
| CAS號 | 456-12-2 |
| 分子式 | C18H19NO3 |
| 分子量 | 297.35 |
| EINECS號 | 1533716-785-6 |
| 相關(guān)類別 | 保健品添加劑;中藥對照品 |
| Mol文件 | 456-12-2.mol |
| 結(jié)構(gòu)式 |  |
印枳堿 性質(zhì)
| 熔點 | 178-179℃ |
|---|---|
| 沸點 | 567.7±50.0 °C(Predicted) |
| 密度 | 1.178±0.06 g/cm3(Predicted) |
| 儲存條件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 形態(tài) | 粉末晶體 |
| 酸度系數(shù)(pKa) | 13.70±0.20(Predicted) |
| 顏色 | 白色至淺黃色至淺橙色 |
印枳堿是一種化合物，可以從生長在印度的Aegle marmelos樹的葉子中提取。研究發(fā)現(xiàn)這種樹的精油對21種細(xì)菌有效。印枳堿也有抗肥胖作用。
印枳堿為芳香類衍生物，其可用作醫(yī)藥合成中間體。Aegeline 是一種主要生物堿，模擬酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突觸核蛋白和 Bax 毒性。Aegeline 恢復(fù) αsyn 或 Bax 抑制的酵母細(xì)胞生長。
Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.
安全信息
| 海關(guān)編碼 | 2924.29.7790 |
|---|