- Quercetagetin
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- $90.00 / 1mg
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2024-11-19
- CAS:90-18-6
- Min. Order:
- Purity: 99.76%
- Supply Ability: 10g
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| | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE Basic information |
| Product Name: | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE | | Synonyms: | QUERCETAGIN;QUERCETAGENIN;QUERCETAGETIN;3,3',4',5,6,7-HEXAHYDROXYFLAVONE;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone;2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one;3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one | | CAS: | 90-18-6 | | MF: | C15H10O8 | | MW: | 318.24 | | EINECS: | 201-973-6 | | Product Categories: | Flavanols | | Mol File: | 90-18-6.mol |  |
| | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE Chemical Properties |
| Melting point | >300°C | | Boiling point | 732.4±60.0 °C(Predicted) | | density | 1.912±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (392.79 mM; Need ultrasonic) | | form | A crystalline solid | | pka | 6.12±0.40(Predicted) | | color | Light yellow to yellow | | LogP | 2.230 (est) |
| | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE Usage And Synthesis |
| Uses | Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties. | | Definition | ChEBI: A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively. | | Biological Activity | Cell permeable: yes', 'Primary Target
PIM1 kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 340 nM against PIM1 kinase | | in vivo | Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3]. | Animal Model: | SKH-1 hairless mice model[3] | | Dosage: | 4 or 20 nmol | | Administration: | Topical application; 28 weeks | | Result: | Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model. |
| | IC 50 | PIM1: 0.34 μM (IC50); PIM2: 3.45 μM (IC50); RSK2: 2.82 μM (IC50); PKA: 21.2 μM (IC50) | | References | [1] Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7. DOI:10.1002/jsfa.4402
[2] Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72. DOI:10.1158/1535-7163.MCT-06-0397
[3] Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. DOI:10.1016/j.jmb.2012.10.019 |
| | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE Preparation Products And Raw materials |
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