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| | N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT Basic information |
| Product Name: | N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT | | Synonyms: | 2-deoxy-2,3-dehydro-n-acetylneuraminicacid;N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT;N-ACETYL-2,3-DEHYDRO-2-DEOXYNEURAMINIC ACID;N-ACETYL-2,3-DEHYDRO-2-DEOXYNEURAMINIC ACID SODIUM SALT;1,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID;2,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID;N-acetyl-2,3-didehydro-2-deoxyneuraminic acid;N-ACETYL-2 3-DEHYDRO-2-DEOXYNEURAMINIC & | | CAS: | 24967-27-9 | | MF: | C11H17NO8 | | MW: | 291.25 | | EINECS: | 246-550-7 | | Product Categories: | Pharm intermediate;Intermediates | | Mol File: | 24967-27-9.mol |  |
| | N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT Chemical Properties |
| Melting point | 227-228 | | Boiling point | 773.4±60.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: soluble50mg/mL, clear, colorless | | pka | 3.90±0.70(Predicted) | | form | Solid | | color | White to Pale Yellow | | optical activity | [α]20/D 40.8 to 51.0 °, c =0.66% (w/v) in water | | biological source | synthetic (organic) | | Water Solubility | water: 1mM | | BRN | 8722455 | | CAS DataBase Reference | 24967-27-9 |
| | N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT Usage And Synthesis |
| Uses | Neuraminidase (sialidase) inhibitor | | Uses | N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt is a bacterial, viral, and mammalian neuraminidase inhibitor. It can be used in biological study of knockdown of Neu4 and injection of sialidase inhibitor such as DANA resulted in impairment of long-term potentiation at mossy fiber-CA3 synapses and hippocampus-dependent spatial memory in rats. | | Definition | ChEBI: N-Acetylneuraminic acid reduced across the 2,3-bond with loss of the hydroxy group at C-2; it is a minor component of body fluids although abundant in sialuria. | | Biological Activity | Inhibitor of bacterial, viral and animal neuraminidase (sialidase). | | in vivo | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model[3]. | Animal Model: | Mice (Mouse model of pulmonary fibrosis)[3] | | Dosage: | 10?mg/kg | | Administration: | I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21) | | Result: | Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
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| | N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT Preparation Products And Raw materials |
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