伊曲茶堿雜質(zhì)
| 中文名稱 | 伊曲茶堿雜質(zhì) |
|---|---|
| 中文同義詞 | 伊曲茶堿雜質(zhì)14;4-去甲基伊曲茶堿;4-去甲基異氟烷;伊曲茶堿雜質(zhì)869 |
| 英文名稱 | 4-DesMethyl Istradefylline |
| 英文同義詞 | (E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione;4-DesMethyl Istradefylline impurity;Istradefylline Impurity 14;1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI);Istradefylline 4-O-Desmethyl Impurity;Istradefylline M1 metabolite;Itraphylline impurities869;Itraphylline impurities6 |
| CAS號 | 160434-48-0 |
| 分子式 | C19H22N4O4 |
| 分子量 | 370.4 |
| EINECS號 | |
| 相關(guān)類別 | 雜質(zhì)對照品;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 160434-48-0.mol |
| 結(jié)構(gòu)式 |  |
伊曲茶堿雜質(zhì) 性質(zhì)
| 沸點 | 604.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 9.88±0.31(Predicted) |
4-Desmethyl Istradefylline 是 Istradefylline 的代謝物。Istradefylline 是一種有效的，選擇性的，可口服的 adenosine A2A receptor 拮抗劑，在帕金森疾病模型試驗中，Ki 值為 2.2 nM。
用途
4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh
ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.