阿魏酸甲酯
| 中文名稱(chēng) | 阿魏酸甲酯 |
|---|---|
| 中文同義詞 | 4-羥基-3-甲氧基肉桂酸甲酯,99%;4-羥基-3-甲氧基肉桂酸甲酯;阿魏酸甲酯 5G;優(yōu)選]FERULIC ACID METHYL ESTER;優(yōu)選]阿魏酸甲酯;阿魏酰甲酯;FERULIC ACID METHYL ESTER,ANTIOXIDANT AGENT;阿魏酸甲酯,10 MM DMSO 溶液 |
| 英文名稱(chēng) | FERULIC ACID METHYL ESTER |
| 英文同義詞 | Methyl Ferulate [4-Hydroxy-3-MethoxycinnaMic Acid Methyl Ester];METHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)-ACRYLATE;METHYL 3-(4-HYDROXY-3-METHOXY)CINNAMATE;FERULIC ACID METHYL ESTER;4-HYDROXY-3-METHOXYCINNAMIC ACID METHYL ESTER;3-(4-hydroxy-3-methoxyphenyl)-2-propenoicacimethylester;4-hydroxy-3-methoxy-cinnamicacimethylester;3-(3-Methoxy-4-hydroxyphenyl)acrylic acid methyl ester |
| CAS號(hào) | 2309-07-1 |
| 分子式 | C11H12O4 |
| 分子量 | 208.21 |
| EINECS號(hào) | 1308068-626-2 |
| 相關(guān)類(lèi)別 | 日化用品;植物提取物;醫(yī)藥中間體;醫(yī)藥原料;有機(jī)原料;抗衰老劑;Aromatic Esters;原料藥;標(biāo)準(zhǔn)品;原料中間體-原料藥;有機(jī)化工原料;美白防曬;原料;標(biāo)準(zhǔn)品;中藥對(duì)照品;化工原料;化妝品原料 |
| Mol文件 | 2309-07-1.mol |
| 結(jié)構(gòu)式 |  |
阿魏酸甲酯 性質(zhì)
| 熔點(diǎn) | 62-65°C |
|---|---|
| 沸點(diǎn) | 163 °C(Press: 1 Torr) |
| 密度 | 1.204±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 丙酮（少量溶解）、氯仿（少量溶解）、乙酸乙酯（少量溶解） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 8.88±0.18(Predicted) |
| 顏色 | 白色至類(lèi)白色 |
| 水溶解性 | Slightly soluble in water. |
| LogP | 2.209 (est) |
| CAS 數(shù)據(jù)庫(kù) | 2309-07-1(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester(2309-07-1) |
Ferulic acid methyl ester (Methyl ferulate) 是從 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能夠透過(guò)細(xì)胞膜和血腦屏障，清除自由基，可用于神經(jīng)退行性疾病的研究。在原發(fā)性骨髓源性巨噬細(xì)胞中，F(xiàn)erulic acid methyl ester 抑制 COX-2 的表達(dá)，降低 p-p38 和 p-JNK 的水平。
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p38
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Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).
Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.
Cell Viability Assay
| Cell Line: | Primary bone marrow derived-macrophages (BMDMs) |
| Concentration: | 25 μg/mL |
| Incubation Time: | 6 h, 18 h, 48 h |
| Result: | Showed no cytotoxic effects on BMDMs. |
Western Blot Analysis
| Cell Line: | RAW 246.7 cells |
| Concentration: | 10 μg/mL and 25 μg/mL |
| Incubation Time: | For 1 h before stimulation with LPS |
| Result: | Significantly suppressed COX-2 expression at 25 μg/mL. |
化學(xué)性質(zhì)
白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于番杏科(Aizoaceae) 番杏 Tetragonia tetragonoides (Pall.)O.kuntze 葉。用途
阿魏酸甲酯具有殺線(xiàn)蟲(chóng)性；抗炎；抗腫瘤的作用。用途
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等安全信息
| 危險(xiǎn)類(lèi)別碼 | 36/37/38 |
|---|---|
| 安全說(shuō)明 | 26-36/37/39 |
| RTECS號(hào) | GD9470000 |
| 海關(guān)編碼 | 2918999090 |