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| TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE Basic information |
| TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE Chemical Properties |
Melting point | 56-57 °C(lit.) | Boiling point | 367.9±34.0 °C(Predicted) | density | 1.37±0.1 g/cm3(Predicted) | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | form | Solid | color | White to off-white |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | WGK Germany | 3 | HS Code | 2933998090 |
| TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE Usage And Synthesis |
Uses | N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination[1]. | General Description | N-Boc-5-bromoindole can undergo Sonogashira coupling reaction with N,N-diisopropylprop-2-ynylamine to afford the corresponding propargylic diisopropylamine. N-Boc-5-bromoindole is formed as an intermediate during the synthesis of 2-(5-substituted-1H-indol-3-yl)-N-hydroxyacetamide derivatives. | References | [1] Christoffer Bengtsson, et al. Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug. Molecules. 2023 Jun 16;28(12):4818. DOI:10.3390/molecules28124818 |
| TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE Preparation Products And Raw materials |
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