ALDOSTERONE
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ALDOSTERONE ??
- ???
- 170-172°C
- ??
- D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
- ?? ?
- 412.46°C (rough estimate)
- ??
- 1.28
- ???
- 1.6120 (estimate)
- ???
- 2℃
- ?? ??
- Sealed in dry,Room Temperature
- ???
- ???(?? ???), ?????(?? ???), DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 12.98±0.10(Predicted)
- ??? ??
- ??? ??
- ??
- ???
- optical activity
- +14523 (c 0.99, acetone)
- ???
- 51.18mg/L(37℃)
- Merck
- 13,224
- BRN
- 3224996
- CAS ??????
- 52-39-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,Xn,F | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-36-20/21/22-11 | ||
| ????? | 22-24/25-36-26-36/37-16 | ||
| ????(UN No.) | UN 1648 3 / PGII | ||
| WGK ?? | 3 | ||
| RTECS ?? | TU4523000 | ||
| F ?????? | 22-24-25 | ||
| HS ?? | 29372900 |
ALDOSTERONE C??? ??, ??, ??
??
Aldosterone is a mineralocorticosteroid that takes part in the regulation of electrolytic balance in the organism. Aldosterone lowers excretion of sodium ions from the body, thus increasing their reabsorption and increasing secretion of potassium ions in renal tubules. Being a competitive antagonist of aldosterone, spironlactone blocks aldosterone receptors, thus increasing excretion of sodium, chloride, and corresponding equivalents of water with urine, thus retaining the amount of potassium ions in the organism. Spironolactone is used both individually as well as in combination with thiazides, since it lowers kaliuresis caused by thiazide diuretics.??? ??
White Solid??
Labelled Aldosterone. Aldosterone is an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid pr oduced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal.??
ChEBI: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, i creased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.????
Aldosterone(Aldocortin; electrocortin; mineralocorticoid; 18-oxocorticosterone): (1)Maintenance of normal electrolyte blood balances;(2)Prolongs survival of adrenalectomized animals;(3)Accelerates gluconeogenesis;(4)Regulates kidney function.Purification Methods
Crystallise aldosterone from aqueous acetone. It exists in solution as an equilibrium mixture of free aldehyde and its cyclic hemiacetal, favouring the hemiacetal. The 21-acetate crystallises from Me2CO/Et2O or CH2Cl2/EtOAc and has m 198-199o, [] D +121.7o (c 0.7, CHCl3). [Barton et al. J Chem Soc Perkin Trans 1 2243 1975, Beilstein 8 IV 3491.]ALDOSTERONE ?? ?? ? ???
???
Sodium triacetoxyborohydride
D-ALDOSTERONE 21-ACETATE
Pregn-4-en-18-oic acid, 11,21-dihydroxy-3,20-dioxo-, γ-lactone, (11β)- (9CI)
Pregn-4-en-18-oic acid, 21-(acetyloxy)-11-hydroxy-3,20-dioxo-, γ-lactone, (11β)- (9CI)
Pregn-5-en-18-oic acid, 3,3:20,20-bis[1,2-ethanediylbis(oxy)]-11,21-dihydroxy-, γ-lactone, (11β)- (9CI)
?? ??
ALDOSTERONE ?? ??
???( 189)?? ??
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ALDOSTERONE ?? ??:
D-ALDOSTERONE 21-ACETATE,ALDOSTERONE 21-ACETATE
D-ALDOSTERONE 18,21-DIACETATE
ALDOSTERONE 3-CMO : BSA
ALDOSTERONE SECRETION INHIBITING FACTOR (1-35) (BOVINE)
Aldosterone ELISA
ALDOSTERONE, D-[1,2-3H(N)]-,[1,2-3H]ALDOSTERONE
ANTI-ALDOSTERONE-3
ALDOSTERONE LABELING POSITION:3
ALDOSTERONE 3-CMO : HISTAMINE
ALDOSTERONE SODIUM SULPHATE
[1,2,6,7-3H]ALDOSTERONE,ALDOSTERONE, [1,2,6,7-3H]-,ALDOSTERONE, D [1,2,6,7-3H(N)]
ALDOSTERONE 18,21-DIACETATE
ALDOSTERONE GAMMA LACTONE
Aldosterone, bis(O-trimethylsilyl-)
D-ALDOSTERONE 21-HEMISUCCINATE*CRYSTALLINE
ALDOSTERONE-3-BSA,RABBITANTI-:RIA
ALDOSTERONE ANTI- KV FOR 3H
MAb to Aldosterone Purified (1)