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5'-CHLORO-5'-DEOXYADENOSINE

5'-CHLORO-5'-DEOXYADENOSINE ??? ???
?? ??:
892-48-8
???:
5'-CHLORO-5'-DEOXYADENOSINE
???(??):
Ribavirin Impurity 63;5'-Cl-5'-deoxyadenosine;5'-Chloro-5'-deoxyadenosin;5’-chloro-5’-deoxy-adenosin;5'-CHLORO-5'-DEOXYADENOSINE;5'-Deoxy-5'-chloroadenosine;Adenosine,5'-chloro-5'-deoxy-;5'-CHLORO-5'-DEOXY-D-ADENOSINE;5-CHLORO-5-DEOXYADENOSINE HYDRATE;5'-CHLORO-5'-DEOXYADENOSINE USP/EP/BP
CBNumber:
CB4706654
???:
C10H12ClN5O3
??? ??:
285.69
MOL ??:
892-48-8.mol

5'-CHLORO-5'-DEOXYADENOSINE ??

???
187 °C (exothermic decomp onset @144.5 C)(lit.)
?? ?
645.6±65.0 °C(Predicted)
??
2.03±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Sealed in dry,2-8°C
???
DMSO(?? ???), ?(?? ???, ??)
?? ?? (pKa)
13.03±0.70(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
RTECS ?? AU7357200
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

5'-CHLORO-5'-DEOXYADENOSINE C??? ??, ??, ??

??

5''-Deoxy-5''-chloroadenosine is an intermediate in the synthesis of 5''-Deoxy-5''-(methylthio)adenosine (D242600), a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.

5'-CHLORO-5'-DEOXYADENOSINE ?? ?? ? ???

???

?? ??

???????? 5'-???-S-????-L-?????? S-????-3-??????? 5'-deoxy-5'-fluoroadenosine S-????-L-????

5'-CHLORO-5'-DEOXYADENOSINE ?? ??

???( 148)?? ??
??? ?? ??? ?? ?? ? ??
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5'-CHLORO-5'-DEOXYADENOSINE ?? ??:

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