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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate ??? ???
?? ??:
132335-47-8
???:
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
???(??):
Duloxetine Impurity 52;Duloxetine intermediate;Duloxetine N-Methyl Oxalate;N-Methyl Duloxetine Oxalate;Duloxetine N-methyl Impurity;Duloxetine Impurity 8 Oxalate;S-(+)-N,N-Dimethyl-3-(1-naphtho;Duloxetine Impurity 8(Oxalicacid);N-Methyl Duloxetine Oxalate;Duloxetine N-Methyl (S)-Isomer Oxalate
CBNumber:
CB3855078
???:
C21H23NO5S
??? ??:
401.48
MOL ??:
132335-47-8.mol

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate ??

???
>145°C (dec.)
?? ??
under inert gas (nitrogen or Argon) at 2–8 °C
???
DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
??
???? ?????
CAS ??????
132335-47-8(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H228 ??? ?? ??? ?? ?? 1
?? 2		 ??
??		 GHS hazard pictograms P210, P240,P241, P280, P370+P378
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H313 ??? ???? ??? ? ?? ?? ?? ?? - ?? ?? 5 P312
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P280, P305+P351+P338, P310
??????:
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P310 ?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P330 ?? ?????.
P403+P233 ??? ??? ? ?? ?? ??? ???? ?????.

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate C??? ??, ??, ??

??? ??

White Solid

??

A duloxetine impurity.

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate ?? ?? ? ???

???

?? ??

(S)-(+)-N,N-???-3-(1-???????)-3-(2-???)?????

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate ?? ??

???( 192)?? ??
??? ?? ??? ?? ?? ? ??
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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate ?? ??:

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