Tamsulosin hydrochloride
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Tamsulosin hydrochloride ??
- ???
- 228-230°C
- ??
- D24 -4.0° (c = 0.35 in methanol)
- RTECS ??
- DB2430000
- ?? ??
- 2-8°C
- ???
- DMSO: >10mg/mL
- ??? ??
- ????
- ??
- ???? ?????
- Merck
- 14,9049
- InChIKey
- ZZIZZTHXZRDOFM-XFULWGLBSA-N
- SMILES
- C1(S(=O)(=O)N)=CC(=CC=C1OC)C[C@@H](C)NCCOC1C=CC=CC=1OCC.Cl |&1:13,r|
- CAS ??????
- 106463-17-6(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26 | ||
| WGK ?? | 3 | ||
| HS ?? | 29350090 |
Tamsulosin hydrochloride C??? ??, ??, ??
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Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.??? ??
White to Off-White Solid??
Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy?? ??
Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.???
Moderately toxic by ingestion.???? ??
Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .Tamsulosin hydrochloride ?? ?? ? ???
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Palladium hydroxide
Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]imino]propyl]-2-methoxy-
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Tamsulosin hydrochloride ?? ??
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