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??????
?????? ??? ???
?? ??:
992-21-2
???:
??????
???(??):
??????
???:
lymecycline
???(??):
Tetralysal;Armyl;Tertamyl;Tetramyl;Mucomycin;Tetralisal;Lymecycline;Limeciclina;Vebicyclysal;Lymecycline (85%)
CBNumber:
CB2891297
???:
C29H38N4O10
??? ??:
602.63
MOL ??:
992-21-2.mol
MSDS ??:
SDS

?????? ??

???
192.5°C
?? ?
648.97°C (rough estimate)
??
1.53
???
1.5500 (estimate)
?? ??
Amber Vial, -86°C Freezer, Under inert atmosphere
???
?? ?? ? ??, ???(96%)? ?? ???, ??????? ?? ?? ????.
??? ??
??
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??? ??
?? ?? (pKa)
2.50±0.24(Predicted)
??
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???, ?? ???
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
???? ?? KE-11173
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? GHS hazard pictograms P261, P271, P304+P340, P312
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P272 ??? ??? ??? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P285 ??? ? ?? ?? ???? ??? ???? ?????
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P304+P341 ???? ??,??? ??? ?? ??? ??? ??? ?? ??? ??? ???? ?? ??? ??? ??? ?
P312 ???? ??? ????(??)? ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P342+P311 ??? ??? ???? ????(??)? ??? ????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.

?????? C??? ??, ??, ??

??? ??

Yellow, hygroscopic powder.

??

Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.

??

ChEBI: A tetracycline-based broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall.

Pharmaceutical Applications

2-N-lysinomethyl-tetracycline. A water-soluble prodrug of tetracycline available for oral administration.
Its antimicrobial activity is due to the tetracycline content. It is lipophilic, rapidly absorbed from the gastrointestinal tract and widely distributed. Concentrations around 1 mg/kg have been found in maxillary sinus tissue some 3 h after administration of a conventional dose. The half-life is 7–14 h. Approximately 30% of an orally administered dose is excreted as active drug in the urine, where it achieves concentrations of 300 mg/L.
Its untoward effects and clinical uses are those of tetracycline, although it is claimed to be better tolerated.

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