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IC 261

IC 261 ??? ???
?? ??:
186611-52-9
???:
IC 261
???(??):
CS-1551;IC261, >98%;SU-5607 IC 261;IC-261(SU-5607);IC261, 10 mM in DMSO;IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;IC 261, CK1delta and CK1epsilon inhibitor;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one;(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one
CBNumber:
CB2503626
???:
C18H17NO4
??? ??:
311.335
MOL ??:
186611-52-9.mol
MSDS ??:
SDS

IC 261 ??

???
214 °C
?? ??
protect from light
???
DMSO: 18 mg/mL ???
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
HS ?? 2933.79.8500
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

IC 261 C??? ??, ??, ??

?? ??

A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.

Biochem/physiol Actions

Cell permeable: yes

IC 261 ?? ?? ? ???

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2,4,6-??????????? Oxindole

?? ??

IC 261 ?? ??

???( 93)?? ??
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IC 261 ?? ??:

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