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KP 103

KP 103 ??? ???
?? ??:
164650-44-6
???:
KP 103
???(??):
Efinaconazole;Jublia;Efinaconzole;JUBLIA; KP 103; KP103;(alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;KP 103;Efluconazole;KP 103 USP/EP/BP;Efinaconazole 98%;Efinaconazole 13CD2
CBNumber:
CB21313343
???:
C18H22F2N4O
??? ??:
348.39
MOL ??:
164650-44-6.mol
MSDS ??:
SDS

KP 103 ??

???
192-195°C
?? ?
512.2±60.0 °C(Predicted)
??
1.26±0.1 g/cm3(Predicted)
?? ??
-20°C
???
?????(?? ???), ???(?? ???)
?? ?? (pKa)
12.11±0.29(Predicted)
??? ??
??
??
???? ????
??? (Optical Rotation)
[α]/D -85 to -95°, c = 1 in chloroform
InChI
InChI=1/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/s3
InChIKey
NFEZZTICAUWDHU-GKGMEZMPNA-N
SMILES
N1([C@H](C)[C@@](C2=CC=C(F)C=C2F)(CN2C=NC=N2)O)CCC(=C)CC1 |&1:1,3,r|
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
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H361 ?? ?? ????? ??? ??? ??? ??? ???? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
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P201 ?? ? ?? ???? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.

KP 103 C??? ??, ??, ??

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In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC80 =0.125 μg/mL) and Trichophyton rubrum (MIC80 =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine.

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Efinaconazole has been used as:

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ChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes).

KP 103 ?? ?? ? ???

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KP 103 ?? ??

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KP 103 ?? ??:

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