ChemicalBook >?? ???? >TAK-220
TAK-220
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TAK-220 ??
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- 166-167 °C(Solv: ethyl acetate (141-78-6); ethanol (64-17-5))
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- 757.8±60.0 °C(Predicted)
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- 1.208±0.06 g/cm3(Predicted)
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- Store at -20°C
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- DMSO: ??? ? ??
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- ?? ?? (pKa)
- 16.16±0.50(Predicted)
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- White to off-white
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TAK-220 C??? ??, ??, ??
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TAK-220 is an orally bioavailable antagonist of chemokine (C-C motif) receptor 5 (CCR5). It binds to CCR5 (IC50 = 3.5 nM for the human receptor in CHO cells), but not CCR1, CCR2b, CCR3, CCR4, or CCR7. TAK-220 inhibits the binding of chemokine (C-C motif) ligand 5 (CCL5) and CCL3 to CCR5 (IC50s = 3.5 and 1.4 nM, respectively) but does not inhibit binding of CCL4. It inhibits HIV-1 envelope-mediated membrane fusion in a macrophage (M-tropic) R5, but not in a T cell (T-tropic) X4, strain of HIV-1 (IC50s = 0.42 and >1,000 nM, respectively). TAK-220 inhibits the replication of six strains of R5 HIV-1 clinical isolates (EC90 overall mean = 13 nM) and the R5 JR-FL laboratory-adapted strain (EC50 = 0.6 nM), but not of X4 HIV-1 clinical isolates or the X4 IIIB laboratory-adapted strain (EC50s = >10,000 nM for both), in human peripheral blood mononuclear cells (PBMCs).TAK-220 ?? ?? ? ???
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TAK-220 ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32281 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30230 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 19903 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 |
sales-cpd@caerulumpharma.com | China | 3467 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9803 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 |
3193328036@qq.com | China | 29763 | 68 |