2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド
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- CAS番號.
- 113237-20-0
- 化學(xué)名:
- 2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド
- 別名:
- 2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド
- 英語名:
- 2,6-Dichloro-5-fluoronicotinamide
- 英語別名:
- 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE;2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine;CPD2809-A1;Sotorasib Impurity 1;Olutasidenib Impurity 32;2,6-DICHLORO-5-FLUORONICOTIMIDE;2,6-DICHLORO-5-FLUORONICOTINAMIDE;2,6-Dichloro-5-fluoronicotinamide97%;2,6-Dichloro-5-fluoronicotinamide 97%;2,6-Dichloro-3-formamide-5-fluoropyridine
- CBNumber:
- CB5735729
- 化學(xué)式:
- C6H3Cl2FN2O
- 分子量:
- 209.01
- MOL File:
- 113237-20-0.mol
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2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド 物理性質(zhì)
- 融點(diǎn) :
- 160-162
- 沸點(diǎn) :
- 259.0±40.0 °C(Predicted)
- 比重(密度) :
- 1.614±0.06 g/cm3(Predicted)
- 貯蔵溫度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 外見 :
- crystalline solid
- 酸解離定數(shù)(Pka):
- 13.36±0.50(Predicted)
- 色:
- White
- InChI:
- InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12)
- InChIKey:
- ZVYNUGSPFZCYEV-UHFFFAOYSA-N
- SMILES:
- C1(Cl)=NC(Cl)=C(F)C=C1C(N)=O
2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド 価格
もっと(13)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式會社(wako)
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W01COBPY-7347 |
2,6-dichloro-5-fluoropyridine-3-carboxamide |
113237-20-0 |
25g |
￥10000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式會社(wako)
|
W01COBPY-7347 |
2,6-dichloro-5-fluoropyridine-3-carboxamide |
113237-20-0 |
100g |
￥37500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01APOPC6948 |
2,6-Dichloro-5-fluoronicotinamide |
113237-20-0 |
1g |
￥4800 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01APOPC6948 |
2,6-Dichloro-5-fluoronicotinamide |
113237-20-0 |
5g |
￥8600 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01MAS085023 |
2,6-Dichloro-5-fluoronicotinamide |
113237-20-0 |
1g |
￥89700 |
2024-03-01 |
購入 |
2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド 化學(xué)特性,用途語,生産方法
使用
2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer.
合成
A reaction vessel added 2000 mL of phosphorus oxychloride (POCl). The vessel was cooled to 5°-10° C., and 500 g of dry 2,6-Dihydroxy 5-fluoro-3-cyanopyridine was added in portions at a temperature below 30° C. The mixture was heated at 80°-85° C. for 60 minutes and cooled to room temperature. Phosphorus pentachloride (PCls), 2200 g, was added, in portions, to the mixture. After the addition was complete, the mixture was heated to 100°-104° C. The reaction was stopped after about 30 hours. The mixture was cooled to room temperature, and POCl was removed under reduced pressure. 1,2-Dichloroethane (DCE), 2.0 L, was added to the residue, and the mixture was cooled to 5-10°C. in an ice bath. Distilled water, 5000 mL, was added slowly to the mixture, maintaining the temperature below 40°C. After the water addition, the mixture was stirred at room temperature for an hour. The 1,2-dichloroethane (DCE) layer was separated, and the aqueous layer was extracted with DCE. The DCE extracts were combined. The DCE was removed by vacuum distillation. The residual 2,6- dichloro-5-fluoro-3-cyanopyridine product is used in situ for the next step. 2,6- dichloro-5-fluoro-3-cyanopyridine was placed in a 12 L flask, cooled to 5-10°C. in an ice bath, and added 2300 mL of concentrated sulfuric acid. The residual DCE was then removed under vacuum at room temperature. After removal of the DCE, the mixture was heated at 65°-70° C. for 1–2 hours and monitored by HPLC. After about 2 hours, the mixture was cooled to about 10° C. in an ice bath. The further purity obtained 2,6-Dichloro-5-fluoronicotinamide.
2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド 上流と下流の製品情報
原材料
準(zhǔn)備製品
2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド 生産企業(yè)
Global( 220)Suppliers
2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド スペクトルデータ(FT-IR)
113237-20-0(2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド)キーワード:
- 113237-20-0
- 3-PyridinecarboxaMide, 2,6-dichloro-5-fluoro-
- 2,6-Dichloro-5-fluoronicotinamide97%
- 2,6-DICHLORO-5-FLUORONICOTINAMIDE
- 2,6-Dichloro-5-fluoronicotinamide 97%
- CPD2809-A1
- 2,6-DICHLORO-5-FLUORONICOTIMIDE
- 2,6-dichloro-3-carboxamide-5-fluoropyridine
- 2,6-DICHLORO-5-FLUORONICOTINAMIDE ISO 9001：2015 REACH
- 2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine
- 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE
- 2,6-Dichloro-3-formamide-5-fluoropyridine
- Sotorasib Impurity 1
- Olutasidenib Impurity 32
- 2,6-ジクロロ-5-フルオロピリジン-3-カルボキサミド