アルカフタジン
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- CAS番號.
- 147084-10-4
- 化學(xué)名:
- アルカフタジン
- 別名:
- アルカフタジン;アルカフタジン (JAN);ラスタカフト;2-(1-メチルピペリジン-4-イリデン)-4,7-ジアザトリシクロ[8.4.0.03,7]テトラデカ-1(14),3,5,10,12-ペンタエン-6-カルバルデヒド;2-(1-メチルピペリジン-4-イリデン)-4,7-ジアザトリシクロ[8.4.0.03,7]テトラデカン-1(14),3,5,10,12-ペンタエン-6-カルボアルデヒド
- 英語名:
- ALCAFTADINE
- 英語別名:
- R 89674;caftadine;Lastacaft;ALCAFTADINE;Alcaftadine, >=99%;Alcaftadine (R89674);ALCAFTADINE USP/EP/BP;Alcaftadine, 10 mM in DMSO;6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-iMidazo[2,1-b][3]benzazepine-3-carboxaldehyde;5H-IMidazo[2,1-b][3]benzazepine-3-carboxaldehyde,6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-
- CBNumber:
- CB21011726
- 化學(xué)式:
- C19H21N3O
- 分子量:
- 307.39
- MOL File:
- 147084-10-4.mol
- MSDS File:
- SDS
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アルカフタジン 物理性質(zhì)
- 融點 :
- 167 °C
- 沸點 :
- 556.2±60.0 °C(Predicted)
- 比重(密度) :
- 1.24
- 貯蔵溫度 :
- Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- 外見 :
- powder to crystal
- 酸解離定數(shù)(Pka):
- 8.76±0.20(Predicted)
- 色:
- White to Yellow to Orange
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCA514530 |
アルカフタジン
Alcaftadine |
147084-10-4 |
1mg |
￥20600 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCA514530 |
アルカフタジン
Alcaftadine |
147084-10-4 |
5mg |
￥38000 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCA514530 |
アルカフタジン
Alcaftadine |
147084-10-4 |
10mg |
￥56900 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCA514530 |
アルカフタジン
Alcaftadine |
147084-10-4 |
50mg |
￥105900 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCA514530 |
アルカフタジン
Alcaftadine |
147084-10-4 |
250mg |
￥262100 |
2023-06-01 |
購入 |
アルカフタジン 化學(xué)特性,用途語,生産方法
外観
白色～黃色～黃赤色粉末～結(jié)晶
効能
抗アレルギー薬, 抗炎癥薬, H1受容體拮抗薬
説明
Alcaftadine, a histamine H
1/H
2 receptor antagonist, was approved in
the United States in 2010 for the prevention of itching and redness associated
with allergic conjunctivitis. Seasonal and perennial allergic conjunctivitis
affects up to 40% of the population worldwide. There are
numerous treatment options, with topical antihistamines being an effective
therapy. Some of the primary symptoms and signs of allergic conjunctivitis
are ocular itching and conjunctival redness. The pharmaceutical
market for conjunctivitis is substantial and steadily increasing.
使用
Alcaftadine is a H1 histamine receptor antagonist. Alcaftadine is used to prevent eye irritation and treat the signs and symptoms of allergic conjunctivitis.
定義
ChEBI: An imidazobenzazepine that is 6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergi
conjunctivitis.
臨床応用
Alcaftadine, an ophthalmic histamine H1 receptor antagonist,
was approved by the FDA for the prevention of itching associated
with allergic conjunctivitis and was launched under the trade
name Lastacaft in early 2011. Alcaftadine was discovered by
Janssen Pharmaceuticals and marketed by Vistakon Pharmaceuticals,
both subsidiaries of Johnson & Johnson. However, unlike other marketed drugs, the synthesis of alcaftadine was only mentioned
in the patents filed by Janssen’s scientists approximately twenty
years ago.
アルカフタジン 上流と下流の製品情報
原材料
準(zhǔn)備製品
アルカフタジン 生産企業(yè)
Global( 197)Suppliers
アルカフタジン スペクトルデータ(1HNMR、MS)
147084-10-4(アルカフタジン)キーワード:
- 147084-10-4
- ALCAFTADINE
- 6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-iMidazo[2,1-b][3]benzazepine-3-carboxaldehyde
- R 89674
- 12-(1-Methylpiperidin-4-ylidene)-4,6,7,12-tetrahydrobenzo[d]pyriMido[1,2-a]azepine-3-carbaldehyde
- 5H-IMidazo[2,1-b][3]benzazepine-3-carboxaldehyde,6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-
- Alcaftadine, >=99%
- Alcaftadine (R89674)
- Lastacaft
- caftadine
- ALCAFTADINE USP/EP/BP
- Alcaftadine, 10 mM in DMSO
- アルカフタジン
- アルカフタジン (JAN)
- ラスタカフト
- 2-(1-メチルピペリジン-4-イリデン)-4,7-ジアザトリシクロ[8.4.0.03,7]テトラデカ-1(14),3,5,10,12-ペンタエン-6-カルバルデヒド
- 2-(1-メチルピペリジン-4-イリデン)-4,7-ジアザトリシクロ[8.4.0.03,7]テトラデカン-1(14),3,5,10,12-ペンタエン-6-カルボアルデヒド