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ChemicalBook >> CAS DataBase List >>FB23-2

FB23-2

CAS No.
2243736-45-8
Chemical Name:
FB23-2
Synonyms
FB23-2;FB23-2，1.5g;FB23-2, 10 mM in DMSO;FB23-2(FTO Demethylase inhibitor FB23-2);2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide;2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide;Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-;FB23 2,AML,Apoptosis,leukemia,acute,anti-proliferation,Inhibitor,FB232,m6A,myeloid,mRNA,inhibit,FB23-2,demethylase,FB-23-2
CBNumber:
CB84908508
Molecular Formula:
C18H15Cl2N3O3
Molecular Weight:
392.24
MDL Number:
MFCD32174281
MOL File:
2243736-45-8.mol
Last updated:2025-05-14 17:26:45

FB23-2 Properties

Density 1.428±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:70.25(Max Conc. mg/mL);179.1(Max Conc. mM)
form A solid
pka 8.72±0.40(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

FB23-2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biorbyt Ltd orb611563 FB23-2 (FTO Demethylase inhibitor FB23-2) 2243736-45-8 100mg $1654.1 2021-12-16 Buy
Biorbyt Ltd orb611563 FB23-2 (FTO Demethylase inhibitor FB23-2) 2243736-45-8 250mg $3282.7 2021-12-16 Buy
Biorbyt Ltd orb611563 FB23-2 (FTO Demethylase inhibitor FB23-2) 2243736-45-8 1g $6545 2021-12-16 Buy
DC Chemicals DC23119 FB23-2(FTODemethylaseinhibitorFB23-2) >98% 2243736-45-8 1g $2800 2021-12-16 Buy
DC Chemicals DC23119 FB23-2(FTODemethylaseinhibitorFB23-2) >98% 2243736-45-8 100mg $800 2021-12-16 Buy
Product number Packaging Price Buy
orb611563 100mg $1654.1 Buy
orb611563 250mg $3282.7 Buy
orb611563 1g $6545 Buy
DC23119 1g $2800 Buy
DC23119 100mg $800 Buy

FB23-2 Chemical Properties,Uses,Production

Uses

FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML)[1].

in vivo

FB23-2 (2 mg/kg; i.p.; daily; for 10 days) substantially suppresses leukemia progression and prolongs survival[1].
FB23-2 exhibits elimination half-life (rat 6.7 h) and Cmax (rat 2421.3 ng/mL) following intraperitoneal injection (rat 3 mg/kg)[1].

Animal Model:NOD/LtSz-scid IL2RG-SGM3 (NSGS) mice, xeno-transplanted with MONOMAC6 AML cells[1]
Dosage:2 mg/kg
Administration:Intraperitoneal injection, daily, for 10 days
Result:Delayed the onset of full-blown leukemic symptoms and significantly prolonged survival by almost doubling the median survival.
Animal Model:Sprague Dawley (SD) rats[1]
Dosage:3 mg/kg (Pharmacokinetic Analysis)
Administration:Intraperitoneal injection
Result:T1/2 (6.7 hours), Cmax (2421.3 ng/mL).

References

[1] Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. DOI:10.1016/j.ccell.2019.03.006

FB23-2 Preparation Products And Raw materials

Raw materials

Preparation Products

FB23-2 Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1521 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58

View Lastest Price from FB23-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FB23-2 pictures 2025-05-14 FB23-2
2243736-45-8
 US $32.00-123.00 / mg 98.00% 10g TargetMol Chemicals Inc.
  • FB23-2 pictures
  • FB23-2
    2243736-45-8
  • US $32.00-123.00 / mg
  • 98.00%
  • TargetMol Chemicals Inc.

FB23-2 Spectrum

FB23-2 FB23-2(FTO Demethylase inhibitor FB23-2) Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy- FB23-2，1.5g 2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide FB23 2,AML,Apoptosis,leukemia,acute,anti-proliferation,Inhibitor,FB232,m6A,myeloid,mRNA,inhibit,FB23-2,demethylase,FB-23-2 2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide FB23-2, 10 mM in DMSO 2243736-45-8