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FB23-2(FTO Demethylase inhibitor FB23-2)

  Cat. No.:  DC23119   Featured
Chemical Structure
2243736-45-8
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Field of application
FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO, directly bind to FTO, inhibits FTO demethylation of m6 A in RNA in vitro with IC50 of 2.6 uM.
Cas No.: 2243736-45-8
Chemical Name: 2-((2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide
SMILES: CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl
Formula: C18H15Cl2N3O3
M.Wt: 392.236
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM[1].
Target: IC50: 2.6 μM (FTO)[1]
In Vivo: FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice[1].
In Vitro: FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells[1]. FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM[1].
References: [1]. Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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