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ChemicalBook >> CAS DataBase List >>MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2

CAS No.
158584-09-9
Chemical Name:
MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2
Synonyms
NFF-3;NFF-2;MMP SUBSTRATE-2;MMP-3 Substrate (NFF-3);MCA-RPKPVE-NVAL-WRK(DNP)-NH2;MCA-RPKPYA-NVA-WM-K(DNP)-NH2;MCA-RPKPVE-NVA-WR-K(DNP)-NH2;Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2;FLUORESCENT PEPTIDE SUBSTRATE II;MMP-3/MMP-9 FRET substrate、NFF-3
CBNumber:
CB8235134
Molecular Formula:
C78H110N22O20
Molecular Weight:
1675.84
MDL Number:
MFCD00671420
MOL File:
158584-09-9.mol
Last updated:2025-04-18 09:52:53

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Properties

Density 1.49±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
form A crystalline solid
pka 4.44±0.10(Predicted)
color yellow
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22188 NFF-3 ≥95% 158584-09-9 1mg $93 2024-03-01 Buy
Cayman Chemical 22188 NFF-3 ≥95% 158584-09-9 5mg $388 2024-03-01 Buy
AK Scientific 2595CW (4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-1-[(2S)-5-carbamimidamido-2-[[2-(7-methoxy-2-oxochromen-4-yl)acetyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-6-(2,4-dinitroanilino)-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoicacid 158584-09-9 5mg $530 2021-12-16 Buy
American Custom Chemicals Corporation PEP0002643 NFF - 3 95.00% 158584-09-9 1MG $654.89 2021-12-16 Buy
Chem-Impex 32878 Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2trifluoroacetatesalt 158584-09-9 5MG $1044.83 2021-12-16 Buy
Product number Packaging Price Buy
22188 1mg $93 Buy
22188 5mg $388 Buy
2595CW 5mg $530 Buy
PEP0002643 1MG $654.89 Buy
32878 5MG $1044.83 Buy

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Chemical Properties,Uses,Production

Uses

NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1].

Biological Activity

Cell permeable: no', 'Primary Target
Matrix Metalloproteinases (MMPs)', 'Product does not compete with ATP.', 'Reversible: no', 'kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)

IC 50

MMP-3; MMP-10

References

[1] Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45. DOI:10.1016/j.ab.2010.09.040

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Suppliers

Global( 77)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5221 58
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42957 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15402 60
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS: DNP-NH2 [MCA-RPKPYA-NVA-WM-K: DNP-NH2] MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2] 7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-val-G 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-VAL-GLU Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE (7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE (7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-VALYL-L-GLUTAMYL-L-NORVALYL-L-TRYPTOPHYL-L-ARGINYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE MCA-RPKPYA-NVA-WM-K(DNP)-NH2 MCA-RPKPVE-NVAL-WRK(DNP)-NH2 MCA-RPKPVE-NVA-WR-K(DNP)-NH2 MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(DNP)-NH2 MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(NDP)-NH2 MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2 FLUORESCENT PEPTIDE SUBSTRATE II NFF-3 NFF-2 MOCAC-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 MOCAC-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2 MMP SUBSTRATE-2 L-Lysinamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-valyl-L-α-glutamyl-L-norvalyl-L-tryptophyl-L-arginyl-N6-(2,4-dinitrophenyl)- MMP-3 Substrate (NFF-3) 390 MMP Substrate XIII, NFF-3 - 1 mg Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt MMP-3/MMP-9 FRET substrate、NFF-3 158584-09-9 C78H110N22O20 Activity BioChemical Cell Signaling and Neuroscience Cell Biology Extracellular Matrix Fluorogenic Metalloproteinase Substrates Cytoskeleton and Extracellular Matrix peptide Activity Enzyme Substrates Fluorogenic