4-Bromo-3-(trifluoromethyl)phenol
- CAS No.
- 320-49-0
- Chemical Name:
- 4-Bromo-3-(trifluoromethyl)phenol
- Synonyms
- 4-bromo-3-trifluromethylphenol;3-TRIFLUOROMETHYL-4-BROMO PHENOL;4-BROMO-3-(TRIFLUOROMETHYL)PHENOL;2-BROMO-5-HYDROXYBENZOTRIFLUORIDE;Phenol,4-bromo-3-(trifluoromethyl)-;4-BROMO-3-TRIFLUOROMETHYLPHENOL 98%;2-Bromo-5-hydroxybenzotrifluoride99%;2-Bromo-5-hydroxybenzotrifluoride 99%;4-Bromo-3-(trifluoromethyl)phenol >4-Bromo-3-(trifluoromethyl)phenol,98%
- CBNumber:
- CB7702051
- Molecular Formula:
- C7H4BrF3O
- Molecular Weight:
- 241.01
- MDL Number:
- MFCD03095342
- MOL File:
- 320-49-0.mol
| Melting point | 44-46°C |
|---|---|
| Boiling point | 61-63 °C(Press: 3.5-4.0 Torr) |
| Density | 1.752±0.06 g/cm3(Predicted) |
| Flash point | >110°(230°F) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 8.39±0.18(Predicted) |
| form | Solid |
| color | Yellow |
| InChI | InChI=1S/C7H4BrF3O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H |
| InChIKey | VOWPIDJSINRFPZ-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C(C(F)(F)F)=C1 |
| CAS DataBase Reference | 320-49-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H314-H318 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2908190090 | |||||||||
| NFPA 704 |
|
4-Bromo-3-(trifluoromethyl)phenol price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4494 | 4-Bromo-3-(trifluoromethyl)phenol >98.0%(GC) | 320-49-0 | 1g | $23 | 2025-07-31 | Buy |
| TCI Chemical | B4494 | 4-Bromo-3-(trifluoromethyl)phenol >98.0%(GC) | 320-49-0 | 5g | $65 | 2025-07-31 | Buy |
| TRC | B695960 | 4-Bromo-3-(trifluoromethyl)phenol | 320-49-0 | 1g | $75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0018759 | 2-BROMO-5-HYDROXYBENZOTRIFLUORIDE 95.00% | 320-49-0 | 1G | $647.36 | 2021-12-16 | Buy |
| AK Scientific | J98124 | 4-Bromo-3-(trifluoromethyl)phenol | 320-49-0 | 5g | $30 | 2021-12-16 | Buy |
4-Bromo-3-(trifluoromethyl)phenol Chemical Properties,Uses,Production
Chemical Properties
light yellow crystalline powder
Synthesis
98-17-9
320-49-0
General procedure for the synthesis of 3-trifluoromethyl-4-bromophenol from 3-trifluoromethylphenol: To a solution of 3-trifluoromethylphenol (7.50 mL, 62 mmol) was added dropwise bromine (3.47 mL, 68 mmol) and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was poured into water and extracted with dichloromethane. The organic layers were combined and washed sequentially with 4% sodium bicarbonate solution and saturated saline. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate solvent mixture as mobile phase. Finally, 5.17 g of 3-trifluoromethyl-4-bromophenol was obtained in 30% yield. lRMS: m/z 241 (M-1)+; retention time: 6.18 min (Method B). 1H NMR (400 MHz, CDCl3) δ 7.53 (d, J = 8.6 Hz, 1H), 7.19 (d, J = 2.9 Hz, 1H), 6.87 (dd. J = 8.6, 2.9 Hz, 1H), 5.98 (s, 1H).
References
[1] Patent: WO2011/35900, 2011, A1. Location in patent: Page/Page column 80
[2] Patent: WO2004/35556, 2004, A1. Location in patent: Page 94
[3] Patent: US5183934, 1993, A
[4] Patent: EP423991, 1991, A2
4-Bromo-3-(trifluoromethyl)phenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
View Lastest Price from 4-Bromo-3-(trifluoromethyl)phenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-02 | 2-Bromo-5-hydroxybenzotrifluoride
320-49-0
|
US $1.00 / KG | 1KG | Min98%HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 2-Bromo-5-hydroxybenzotrifluoride
320-49-0
- US $1.00 / KG
- Min98%HPLC
- Career Henan Chemical Co
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