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ChemicalBook >> CAS DataBase List >>Pranlukast

Pranlukast

CAS No.
103177-37-3
Chemical Name:
Pranlukast
Synonyms
Onon;rs411;Ultair;ono1078;Prenast;Prandtl;Pranlukas;ONO-RS-411;emihydrate;PRANLUKAST
CBNumber:
CB3271355
Molecular Formula:
C27H23N5O4
Molecular Weight:
481.5
MDL Number:
MFCD00864631
MOL File:
103177-37-3.mol
MSDS File:
SDS
Last updated:2025-05-07 18:39:43

Pranlukast Properties

Melting point 236-238°C
Density 1.374±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 25 mg/ml)
form solid
pka 4.96±0.10(Predicted)
color White
Merck 14,7710
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference 103177-37-3(CAS DataBase Reference)
FDA UNII TB8Z891092
ATC code R03DC02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H413
Precautionary statements  P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  F,C
Risk Statements  11-34
Safety Statements  16-26-36/37/39-45
RTECS  CV5647500
HS Code  2934.99.4400
Toxicity LD50 in male mice (mg/kg): >1000 i.v. (Toda)
NFPA 704
0
2 0

Pranlukast price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P2115 Pranlukast >98.0%(HPLC) 103177-37-3 25mg $39 2024-03-01 Buy
TCI Chemical P2115 Pranlukast >98.0%(HPLC) 103177-37-3 100mg $108 2024-03-01 Buy
Cayman Chemical 10008319 Pranlukast ≥98% 103177-37-3 10mg $19 2024-03-01 Buy
Cayman Chemical 10008319 Pranlukast ≥98% 103177-37-3 100mg $138 2024-03-01 Buy
Cayman Chemical 10008319 Pranlukast ≥98% 103177-37-3 500mg $595 2024-03-01 Buy
Product number Packaging Price Buy
P2115 25mg $39 Buy
P2115 100mg $108 Buy
10008319 10mg $19 Buy
10008319 100mg $138 Buy
10008319 500mg $595 Buy

Pranlukast Chemical Properties,Uses,Production

Asthma drugs

Pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma.
At present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times/d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once/d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times/d.
The above information is edited by the chemicalbook of Tian Ye.

Description

Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.

Chemical Properties

Off-white solid

Originator

Ono (Japan)

Uses

antiasthmatic;leukotriene receptor-1 antagonist

Uses

A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic

Uses

Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.

Definition

ChEBI: N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide is a member of chromones.

brand name

Onon

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

References

1) Nakai?et al. (1988),?New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem.?31?84 2) Taniguchi?et al.?(1993),?The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol.?92?507 3) Ciana?et al.?(2006),?The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J.?25?4615 4) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal.?6?ra93

Pranlukast Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 299)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15531157085; +8615531157085 abby@chuanghaibio.com China 8807 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12778 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504 sales8@hbganmiao.com China 300 58
Shaanxi Xianhe Biotech Co., Ltd 		+8617709210191 Jerry@xhobio.com China 885 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 FandaChem@Gmail.com China 3111 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58

View Lastest Price from Pranlukast manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pranlukast pictures 2025-05-16 Pranlukast
103177-37-3
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
Pranlukast pictures 2025-05-16 Pranlukast
103177-37-3
 US $0.00 / kg 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Pranlukast pictures 2025-05-07 Pranlukast
103177-37-3
 US $72.00-90.00 / mg 99.85% 10g TargetMol Chemicals Inc.
  • Pranlukast pictures
  • Pranlukast
    103177-37-3
  • US $0.00 / KG
  • 99%
  • Hebei Mujin Biotechnology Co.,Ltd
  • Pranlukast pictures
  • Pranlukast
    103177-37-3
  • US $0.00 / kg
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd
  • Pranlukast pictures
  • Pranlukast
    103177-37-3
  • US $72.00-90.00 / mg
  • 99.85%
  • TargetMol Chemicals Inc.

Pranlukast Spectrum

PRANLUKAST 4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox emihydrate ONO-RS-411 ONO-RS-411-01 N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam BenzaMide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)- N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran Pranlukast-d4 Onon Pranlukast (ONO 1078) ono1078 rs411 N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide, ONO-1078, ONO-RS-411, Onon, 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide Pranlukast > Pranlukast RS Pranlukas EP/GMP/FDA Pranlukast Pranlukast USP/EP/BP Pranlukast (1.0mg/ml in DMSO) Pranlukast (10mM in DMSO) Pranlukast D4Q: What is Pranlukast D4 Q: What is the CAS Number of Pranlukast D4 Q: What is the storage condition of Pranlukast D4 Q: What are the applications of Pranlukast D4 Prenast Ultair Prandtl 103177-37-3 C27H23N5O4 API Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Antiasthmatic