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ChemicalBook >> CAS DataBase List >>Doramapimod

Doramapimod

CAS No.
285983-48-4
Chemical Name:
Doramapimod
Synonyms
BIRB 796 (DoraMapiMod);CS-379;CS-1863;BIRB 796;BIBR-796;BIRB 796BS;doramapimod;BIRB-796;BIRB796;DoraMapin BIBR796;BIBR-796(DoraMapiMod)
CBNumber:
CB2855127
Molecular Formula:
C31H37N5O3
Molecular Weight:
527.66
MDL Number:
MFCD09752957
MOL File:
285983-48-4.mol
Last updated:2025-01-27 09:38:02

Doramapimod Properties

Melting point 142-143 °C
Boiling point 631.6±55.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
pka 13.47±0.70(Predicted)
form solid
color White or off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
FDA UNII HO1A8B3YVV
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P301+P312-P302+P352-P305+P351+P338
HS Code  2934999090

Doramapimod price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 506172 p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem 285983-48-4 10mg $172 2024-03-01 Buy
Cayman Chemical 10460 Doramapimod ≥98% 285983-48-4 1mg $26 2024-03-01 Buy
Cayman Chemical 10460 Doramapimod ≥98% 285983-48-4 5mg $50 2024-03-01 Buy
Cayman Chemical 10460 Doramapimod ≥98% 285983-48-4 10mg $87 2024-03-01 Buy
Cayman Chemical 10460 Doramapimod ≥98% 285983-48-4 25mg $153 2024-03-01 Buy
Product number Packaging Price Buy
506172 10mg $172 Buy
10460 1mg $26 Buy
10460 5mg $50 Buy
10460 10mg $87 Buy
10460 25mg $153 Buy

Doramapimod Chemical Properties,Uses,Production

Description

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.

Chemical Properties

Pale Beige Solid

Uses

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Definition

ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.

in vitro

birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].

in vivo

in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].

storage

Store at -20°C

References

1) Pargellis?et al. (2002),?Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol.,?9?268 2) Branger?et al.?(2002),?Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol.,?168?4070 3) Joos?et al. (2010),?Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol.,?160?1252

Doramapimod Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33025 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29865 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58

View Lastest Price from Doramapimod manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Doramapimod pictures 2022-09-08 Doramapimod
285983-48-4
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Doramapimod pictures 2021-07-13 Doramapimod
285983-48-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Doramapimod pictures 2021-07-10 Doramapimod
285983-48-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Doramapimod pictures
  • Doramapimod
    285983-48-4
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • Doramapimod pictures
  • Doramapimod
    285983-48-4
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Doramapimod pictures
  • Doramapimod
    285983-48-4
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Doramapimod Spectrum

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea DoraMapiMod, BIBR-796 BIBR-796(DoraMapiMod) BIRB 796BS N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea DoraMapin BIBR796 DoraMapiMod (BIRB-796) BIRB 796 doramapimod Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]- 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod) Doramapimod 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea DORAMAPIMOD;BIRB 796;BIRB796 3-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1h-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea BIRB 796; BIRB-796; BIRB796; CS-379 BIRB 796 - BIRB 0796 | Doramapimod CS-1863 BIBR-796 BIRB-796;BIRB796 Doramapimod USP/EP/BP BIRB 796 (DoraMapiMod) p38 MAP Kinase Inhibitor X BIRB-796 Doramapimod 1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea Doramapimod, p38 MAPK inhibitor Doramapimod, 10 mM in DMSO 285983-48-4 C31H37N5O3 Anti-cancer&immunity Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators MAPK Inhibitors