天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> CAS DataBase List >>COUMESTROL

COUMESTROL

CAS No.
479-13-0
Chemical Name:
COUMESTROL
Synonyms
Nsc22842;Cumostrol;Cumoestrol;COUMESTROL;COUMOESTROL;cumoesterol;Coumesterol;COUMESTROL(P);Coumestrol,99%;Coumestrol, >98%
CBNumber:
CB2339816
Molecular Formula:
C15H8O5
Molecular Weight:
268.22
MDL Number:
MFCD00016885
MOL File:
479-13-0.mol
Last updated:2025-01-27 09:38:02

COUMESTROL Properties

Melting point ≥350 °C(lit.)
Boiling point 331.39°C (rough estimate)
Density 1.2586 (rough estimate)
refractive index 1.7680 (estimate)
storage temp. Refrigerator
solubility DMSO: soluble
form Light beige solid.
pka 8.25±0.20(Predicted)
color Pale Yellow to Dark Brown
BRN 266702
LogP 2.940 (est)
CAS DataBase Reference 479-13-0(CAS DataBase Reference)
NCI Dictionary of Cancer Terms coumestrol
FDA UNII V7NW98OB34
EPA Substance Registry System Coumestrol (479-13-0)
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DF8077000
F  10
NFPA 704
0
2 0

COUMESTROL price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 27883 Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC) 479-13-0 1mg $97.2 2024-03-01 Buy
Sigma-Aldrich 27883 Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC) 479-13-0 5mg $321 2024-03-01 Buy
Cayman Chemical 11730 Coumestrol ≥98% 479-13-0 1mg $44 2024-03-01 Buy
Cayman Chemical 11730 Coumestrol ≥98% 479-13-0 5mg $93 2024-03-01 Buy
Sigma-Aldrich 27885 Coumestrol ≥95.0% (HPLC) 479-13-0 50mg $386 2024-03-01 Buy
Product number Packaging Price Buy
27883 1mg $97.2 Buy
27883 5mg $321 Buy
11730 1mg $44 Buy
11730 5mg $93 Buy
27885 50mg $386 Buy

COUMESTROL Chemical Properties,Uses,Production

Description

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, ) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).

Chemical Properties

Yellow to Beige Powder

Uses

This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution.

Definition

ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 1151, 1963 DOI: 10.1039/jr9630005127

Biochem/physiol Actions

Coumestrol has anti-estrogenic actions in the brain and pituitary, mediated through estrogen receptor-α.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

References

[1]. chen hy, dykstra kd, birzin et, et al. estrogen receptor ligands. part 1: the discovery of flavanoids with subtype selectivity. bioorg med chem lett. 2004 mar 22;14(6):1417-21.
[2]. hopert ac, beyer a, frank k, et al. characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. environ health perspect. 1998 sep;106(9):581-6.
[3]. wang h, li h, moore lb, et al. the phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane x receptor. mol endocrinol. 2008 apr;22(4):838-57.

COUMESTROL Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29863 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040 1087@dideu.com China 3167 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9641 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58

View Lastest Price from COUMESTROL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CouMestrol pictures 2025-01-03 CouMestrol
479-13-0
 US $0.00-0.00 / KG 5mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
Coumestrol pictures 2024-11-19 Coumestrol
479-13-0
 US $40.00-123.00 / mg 99.23% 10g TargetMol Chemicals Inc.
COUMESTROL pictures 2019-07-06 COUMESTROL
479-13-0
 US $1.00 / KG 1g 99% 100KG Career Henan Chemical Co
  • CouMestrol pictures
  • CouMestrol
    479-13-0
  • US $0.00-0.00 / KG
  • 99%HPLC
  • Shaanxi Dideu Medichem Co. Ltd
  • Coumestrol pictures
  • Coumestrol
    479-13-0
  • US $40.00-123.00 / mg
  • 99.23%
  • TargetMol Chemicals Inc.
  • COUMESTROL pictures
  • COUMESTROL
    479-13-0
  • US $1.00 / KG
  • 99%
  • Career Henan Chemical Co

COUMESTROL Spectrum

cumoesterol COUMOESTROL 7 12-DIHYDROXYCOUMESTAN 98% Coumesterol COUMESTROL(P) 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98% Coumestrol,99% 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone 6H-Benzofuro[3,2-C][1]benzopyran-6-one, 3,9-dihydroxy- Cumoestrol Cumostrol Nsc22842 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic Acid δ-Lactone 7,12-DIHYDROXYCOUMESTAN 7,12-DIHYDROXYCOUMESTANE 7(1), 6-DIHYDROXYCOUMARINO(3(1), 4(1), 3,2)COUMARONE [2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURAN-CARBOXYLIC ACID ALPHA-LACTONE] 2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID DELTA-LACTONE 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE COUMESTROL COUMESTROL BIOREAGENT, SUITABLE FOR 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one 3,9-DIHYDROXY-6H-BENZOFURO[3,2-C]-[1]BENZOPYRAN-6-ONE 2-(2,4-dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylicacidelta-lacton 2-c)(1)benzopyran-6-one,3,9-dihydroxy-6h-benzofuro( 2-c][1]benzopyran-6-one,3,9-dihydroxy-6h-benzofuro[ Coumestrol, >98% 3,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone Coumestrol ( synthitic) 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one Coumestrol (Synthetic) 5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.02,?.011,1?]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaen-9-one 7’, 6-Dihydroxycoumarino(3’, 4’, 3, 2)Coumarone Coumestrol, 10 mM in DMSO 479-13-0 C15H9O5 C15H8O5 Steroids & Hormones - 13C & 2H Steroids Coumarins Iso-Flavones